Yasuharu Hasegawa

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The catalytic, enantioselective, and direct C-N bond formation using unmodified nucleophiles and a nitrogen source such as azodicarboxylates would offer a simple and straightforward procedure for construction of a stereogenic carbon center attached to a nitrogen atom.1 There are many reports on enantioselective direct amination via C-N bond forming reaction(More)
Twofold hydroboration of the bulky Mes*P(vinyl)2 phosphane with Piers' borane [HB(C6F5)2] followed by C6F5/H exchange with 9-BBN generated a reactive P/B/BH FLP structure that cleanly reduced carbon monoxide at the trifunctional frustrated Lewis pair framework to the [B]-formyl stage.
Bulky vinyl phosphanes undergo carbon-carbon coupling with aryl aldehydes with the help of the Lewis acid B(C6F5)3 to give isolable methylene phosphonium products. Dimesityl(vinyl)phosphane undergoes a phospha-Stork reaction with bulky enones efficiently catalyzed by B(C6F5)3 to eventually yield the corresponding substituted cyclobutane products.
Catalytic and stereoselective formation of quaternary carbon centers remains a significant challenge in organic synthetic chemistry. Metal-based catalytic methods including asymmetric alkylation and arylation of carbonyl compounds as well as enantioselective Diels–Alder reactions have been successfully applied for the creation of compounds with chiral(More)
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