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Modulation of the Channel Activity of the ε2/ζ1-Subtype N-Methyl d-Aspartate Receptor by PSD-95*
A channel-associated protein PSD-95 has been shown to induce clustering of N-methyld-aspartate (NMDA) receptors, interacting with the COOH terminus of the ε subunit of the receptors. The effects ofExpand
Differential modulation of NR1‐NR2A and NR1‐NR2B subtypes of NMDA receptor by PDZ domain‐containing proteins
The PSD‐95/Dlg/ZO‐1 (PDZ) domain‐containing proteins MALS and PSD‐95 localize to post‐synaptic densities and bind the COOH‐termini of NR2 subunits of the NMDA receptor. The effects of MALS‐2 andExpand
PSD‐95 eliminates Src‐induced potentiation of NR1/NR2A‐subtype NMDA receptor channels and reduces high‐affinity zinc inhibition
The channel activity of NMDA receptors is regulated by phosphorylation by protein kinases and by interaction with other proteins. Recombinant NR1/NR2A subtype NMDA receptor channels are potentiatedExpand
Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions
Pyrroloquinoline quinone (PQQ) is contained in fruits and vegetables and in human breast milk. It has been reported that PQQ has high reactivity and changes to an imidazole structure (imidazoleExpand
Comparison of the neurotoxicities between volatile organic compounds and fragrant organic compounds on human neuroblastoma SK-N-SH cells and primary cultured rat neurons
These are many volatile organic compounds (VOCs) that are synthesized, produced from petroleum or derived from natural compounds, mostly plants. Fragrant and volatile organic compounds from plantsExpand
Direct activation of GABAA receptors by substances in the organic acid fraction of Japanese sake.
We investigated the effect of substances present in Japanese sake on the response of ionotropic γ-aminobutyric acid (GABA)A receptors expressed in Xenopus oocytes. Sake was fractionated byExpand
Physiological Activities of Perilla Frutescens Var. Frutescens Leaf Extracts and Storage Stability in Kneaded Noodles
P erilla (Perilla frutescens var. frutescens) lea ves w ere fractionated based on their chemical properties , and the physiological activities of the fractions were evaluated . T he acidic fractionExpand