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Modulation of the Channel Activity of the ε2/ζ1-Subtype N-Methyl d-Aspartate Receptor by PSD-95*
TLDR
The results suggest that PSD-95 plays a protective role against neuronal excitotoxicity by decreasing the glutamate sensitivity of the channels and by inhibiting the protein kinase C-mediated potentiation ofThe channels. Expand
Differential modulation of NR1‐NR2A and NR1‐NR2B subtypes of NMDA receptor by PDZ domain‐containing proteins
TLDR
The results indicate that the NR1‐NR2A and NR1-NR2B receptors are modulated differentially by MALS‐2 and PSD‐95, and that similar regulatory effects of PSD-95 on these receptors are achieved by distinct mechanisms. Expand
PSD‐95 eliminates Src‐induced potentiation of NR1/NR2A‐subtype NMDA receptor channels and reduces high‐affinity zinc inhibition
TLDR
The results indicate that PSD‐95 functionally modulates NR1/NR2A channels and explain why Src‐induced potentiation of NMDA receptor currents in hippocampus neurons is not mediated by a reduction in Zn2+ inhibition. Expand
Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions
TLDR
It was shown that PQQ and IPQ improve the memory learning ability of aged mice and that BioPQQ® improves brain function in the language field in humans. Expand
Comparison of the neurotoxicities between volatile organic compounds and fragrant organic compounds on human neuroblastoma SK-N-SH cells and primary cultured rat neurons
TLDR
Comparison of toxicities of n-octanal, nonanal and 2-ethyl-1-hexanol with those of five naturally derived fragrant organic compounds (FOCs) showed lower toxicities than those of VOCs, indicating that FOCs are safer than other compounds. Expand
Direct activation of GABAA receptors by substances in the organic acid fraction of Japanese sake.
TLDR
Intraperitoneal injections of l-lactic acid, gluconic acid, and pyruvic acid, which showed agonistic activity on the GABAA receptor, led to significant anxiolytic effects during an elevated plus-maze test in mice. Expand
Physiological Activities of Perilla Frutescens Var. Frutescens Leaf Extracts and Storage Stability in Kneaded Noodles
P erilla (Perilla frutescens var. frutescens) lea ves w ere fractionated based on their chemical properties , and the physiological activities of the fractions were evaluated . T he acidic fractionExpand
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