Yasuaki Ozawa

Learn More
E-64 isolated from a culture of Aspergillus japonicus is a specific inhibitor of cysteine proteinases. E-64-c, a synthetic analog of E-64, was effective in model animals of muscular dystrophy only when it was given intraperitoneally and by means of osmotic minipump. It showed no effects due to its low absorbability from intestine when it was administered(More)
A simple and convenient method to determine the K+-flux activity of viable human erythrocytes was developed. Erythrocyte suspensions were incubated at 4 degrees C for 24 h to induce K+-release (deltaKr) and then at 37 degrees C for 3 h to influx K+ into erythrocytes (deltaKi). A straight-line relationship between K+ release-influx ratio and ouabain-induced(More)
Coenzyme Q10 (ubidecarenone; CoQ10) was administered at a dose of 60 mg/d either using two conventional formulations or in a lipid microsphere to dogs. Plasma concentrations of CoQ10 were determined by HPLC. The bioavailability of CoQ10 from the lipid microsphere formulation was superior to conventional formulations. These results suggest that three daily(More)
Diurnal variations in serum iron concentration were examined to investigate the influence of sampling time in hemodialysis (HD) patients and healthy subjects. The serum iron concentration and TIBC of HD patients decreased significantly (p<0.01, p<0.01 respectively) compared to those of healthy subjects. Inversely, the serum ferritin concentration of HD(More)