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The measurement of neuron-specific enolase level in serum and cerebrospinal fluid was conducted time-sequentially in an autopsy confirmed patient with Creutzfeld-Jakob disease. The level was markedly high in the early stage of the disease at which time the brain CT showed no or minimal abnormalities, while falling into the normal range in the advanced(More)
Lower motor neurons of the spinal cord of patients with amyotrophic lateral sclerosis (ALS), Werdnig-Hoffmann's disease (WH), X-linked recessive bulbospinal neuronopathy (X-BSNP) and multiple system atrophy (MSA), all of which were known to involve the lower motor neurons, were immunohistochemically examined by using a monoclonal antibody (Ta-51) specific(More)
This report concerns immunocytochemical and ultrastructural studies on the basophilic inclusions in two cases of sporadic juvenile amyotrophic lateral sclerosis (ALS). The inclusion had a globular, irregularshaped, or sometimes fragmented appearance. Ultrastructurally, the inclusions consisted mainly of thick filamentous structures associated with granules.(More)
The pathologic changes in the spinal cord of three autopsied cases associated with ossification of the posterior longitudinal ligament (OPLL) are reported. Compression of the spinal cord was marked at the level of the intervertebral disc, and the spinal cord was strikingly flattened antero-posteriorly. Intensive damage was seen in the gray matter as(More)
Amyotrophic lateral sclerosis (ALS) and adult onset X-linked recessive bulbospinal muscular atrophy (SPMA), constituting the category of adult onset form of motor neuron disease, were analyzed on motor nerve roots. The results of morphometric analysis on ventral spinal roots (VSR) of all spinal segments from ALS and SPMA revealed the following three(More)
  • I. Nakano, Y. Hashizume, T. Tomonaga
  • 1990
In an autopsied case of amyotrophic lateral sclerosis (ALS) with dementia (a 65-year-old man with a 4-year course) showing numerous Bunina bodies in the lower motor neurons including those of cranial motor nuclei, eosinophilic inclusions were also observed in several neurons of the reticular formation of the medulla oblongata. Some of them were confirmed to(More)
  • T. Yasuda, G. Sobue, T. Mitsuma, A. Takahashi, Y. Hashizume
  • 1989
In situ expression of nerve growth factor (NGF) receptors in human dermal and plexiform neurofibroma, schwannoma and traumatic neuroma was examined by an immunohistochemical method using a monoclonal anti-human NGF receptor antibody. Immunoreactivity for the NGF receptor was observed on the principal cells of both neurofibroma and schwannoma. Immunostaining(More)
An in-band optical signal-to-noise ratio (OSNR) monitor is proposed, based on an instantaneous polarization state distribution analysis. The proposed monitor is simple, and is applicable to polarization division multiplexed signals. We fabricate a high-speed Stokes polarimeter that integrates a planar lightwave circuit (PLC) based polarization filter,(More)
This paper proposes a 40Gbit/s-class-λ-tunable WDM/TDM-PON for flexible photonic aggregation networks that achieves the aggregation of a large number of users using the DWBA algorithm without an L2-SW. It also clarifies the scalability of the proposed system in terms of the transmission distance and the number of users. A λ-switching transmission experiment(More)
We propose a high power -tunable burst-mode transmitter with an output of over +10 dBm using a synchronized gain-clamping booster SOA, and demonstrate a 40-dB loss budget and 40-km reach symmetric 40-Gbit/s -tunable WDM/TDM-PON. 1. Introduction Recently, time division multiplexing (TDM)-based high speed optical access system of 10G-EPON and XG-PON has(More)