Yasser Mostafa Kamel

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BACKGROUND & AIMS Thrombocytopenia is common among patients with hepatitis C virus (HCV) infection and advanced fibrosis or cirrhosis, limiting initiation and dose of peginterferon-alfa (PEG) and ribavirin (RBV) therapy. The phase 3 randomized, controlled studies, Eltrombopag to Initiate and Maintain Interferon Antiviral Treatment to Benefit Subjects with(More)
BACKGROUND Patients with myelodysplastic syndrome or acute myeloid leukaemia who are thrombocytopenic and unable to receive disease-modifying therapy have few treatment options. Platelet transfusions provide transient benefit and are limited by alloimmunisation. Eltrombopag, an oral thrombopoietin receptor agonist, increases platelet counts and has(More)
The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcoma (STS) and thrombocytopenia due to treatment with doxorubicin and ifosfamide (AI) combination chemotherapy. Patients aged 18 or older with(More)
Numerous efficacious chemotherapy regimens may cause thrombocytopenia. Thrombopoietin receptor (TPO-R) agonists, such as eltrombopag, represent a novel approach for the treatment of chemotherapy-induced thrombocytopenia. The TPO-R MPL is expressed on megakaryocytes and megakaryocyte precursors, although little is known about its expression on other tissues.(More)
Detection of Brucella species using nucleic acid techniques requires efficient unbiased DNA extraction procedures. In this study, we compared six protocols for DNA isolation from pure culture of Brucella melitenses 16M and the efficiency of different extraction processes were evaluated using Polymerase Chain Reaction (PCR).These protocols included boiling,(More)
Chromosome 7 abnormalities are associated with poor prognosis in myeloid leukaemia. The pathogenetic mechanisms that arise from chromosome 7 rearrangements and lead to malignancy are still poorly understood. The use of leukaemiaderived cell lines might be a useful tool to shed some light on these mechanisms. The cytogenetic characterisation of these cell(More)
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