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SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
ITK (IL-2-inducible T cell kinase), a Tec family protein tyrosine kinase (PTK), is one of three PTKs required for T cell antigen receptor (TCR)-induced activation of phospholipase C-γ1 (PLC-γ1). LikeExpand
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Dual Role of SLP-76 in Mediating T Cell Receptor-induced Activation of Phospholipase C-γ1*
Phospholipase C-γ1 (PLC-γ1) activation depends on a heterotrimeric complex of adaptor proteins composed of LAT, Gads, and SLP-76. Upon T cell receptor stimulation, a portion of PLC-γ1 is recruited toExpand
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Sequential phosphorylation of SLP‐76 at tyrosine 173 is required for activation of T and mast cells
Cooperatively assembled signalling complexes, nucleated by adaptor proteins, integrate information from surface receptors to determine cellular outcomes. In T and mast cells, antigen receptorExpand
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