Yariv Z. Levy

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According to the United Nations, approximately 24.7 million people used amphetamines, 16 million used cocaine, and 12 million used heroin in 2006/07 [Costa, 2008]. Full recovery from drug addiction by chemical treatment and/or social and psychological support is uncertain. The present investigation was undertaken to expand our understanding of the factors(More)
The allostatic theory of drug abuse describes the brain's reward system alterations as substance misuse progresses. Neural adaptations arising from the reward system itself and from the antireward system provide the subject with functional stability, while affecting the person's mood. We propose a computational hypothesis describing how a virtual subject's(More)
Relapse is the chief problem of drug addiction where a successfully abstinent patient returns to seemingly extinct manners of drug consumption. While various parameters were identified as affecting relapse, the general dynamics of drug consumption is yet to be understood. We introduce a model that describes addiction focusing on a single statevalue factor,(More)
Use and misuse of addictive substances has been an ongoing phenomenon from early civilizations to the present. Experimental observations endorse the implication of a cognitive component during the addictive course. The present investigation proposes a learning mechanism affecting the cognitive level of a multiscale model of addiction. Simulations account(More)
Drug addiction is a worldwide epidemic. To reduce its spread, understanding the nature of addiction is crucial and possible treatments have to be developed. Current models of drug addiction only explain why addiction is overwhelming and cannot be overcome. Instead we focus on the dynamic of addiction, which includes rehabilitation and relapse. The model(More)
Personalized medicine is rapidly evolving with the objective of providing a patient with medications based on the "use of genetic susceptibility or pharmacogenetic testing to tailor an individual's preventive care or drug therapy" [1]. It is reasonable to foresee that this domain will incorporate sources of biological knowledge other than genetics including(More)
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