Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation.
A biologically relevant mouse model of WT is generated and one combination of driver alterations for WT is defined, which suggests ERK signaling might contribute to WT development.
Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
- Hongsheng Zhang, Eunchai Kang, Zhiheng Xu
- Biology, PsychologyNature Communications
- 1 June 2016
It is shown that brain-specific Crmp2 knockout mice display molecular, cellular, structural and behavioural deficits, many of which are reminiscent of neural features and symptoms associated with schizophrenia, that reveal a critical role for CRMP2 in neuronal plasticity, neural function and behavioural modulation in mice.
IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice
- Mingcai Li, Yan Li, Xiaojin Liu, Xueming Gao, Yaqing Wang
- Biology, MedicineJournal of Neuroimmunology
- 15 June 2012
Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation
- Lianjun Zhang, Min Chen, F. Gao
- Biology, MedicineProceedings of the National Academy of Sciences
- 16 March 2015
It is found that simultaneous deletion of Wilms’ Tumor Gene 1 (Wt1) and overactivation of Ctnnb1 in Sertoli cells led to Leydig cell-like tumor development, implying that these two cell types most likely originate from the same progenitor cells.
Mea6 controls VLDL transport through the coordinated regulation of COPII assembly
- Yaqing Wang, Liang Liu, Zhiheng Xu
- BiologyCell Research
- 17 June 2016
It is shown that hepatocyte-specific deletion of meningioma-expressed antigen 6 (Mea6)/cutaneous T cell lymphoma-associated antigen 5C (cTAGE5C) leads to severe fatty liver and hypolipemia in mice and evidence is provided that Mea6 plays a critical role in lipid transportation through the coordinated regulation of the COPII machinery.
Globozoospermia and lack of acrosome formation in GM130-deficient mice
- F. Han, Chunyi Liu, Fei Gao
- BiologyCell Death and Disease
- 1 January 2017
The GM130-deficient mouse provides a valuable model for investigating the etiology of human globozoospermia and co-localization of the adaptor protein complex AP1 and trans-Golgi network (TGN) protein TGN46 was disrupted, suggesting that the malformation of acrosomes is most likely due to the defect in the sorting and coating of Golgi-derived pro-acrosomic vesicles.
Methylation of Ribosomal Protein S10 by Protein-arginine Methyltransferase 5 Regulates Ribosome Biogenesis*
- Jinqi Ren, Yaqing Wang, Yuheng Liang, Yongqing Zhang, Shilai Bao, Zhiheng Xu
- Biology, ChemistryJournal of Biological Chemistry
- 16 February 2010
It is shown that ribosomal protein s10 (RPS10) is a novel substrate of an oncoprotein, protein-arginine methyltransferase 5 (PRMT5), and that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg158 and Arg160 residues.
Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression
- Min Chen, Lianjun Zhang, F. Gao
- Biology, MedicineDevelopment
- 1 January 2017
It is demonstrated that Wt1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression, and genital ridge somatic cells have the potential to differentiate into supporting cells or steroidogenic cells depending on Wt 1 gene expression.
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
- Xiaozhen Wang, G. Lu, G. Shao
- BiologyBiochemical and Biophysical Research…
- 14 February 2014
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
- Xiaozhen Wang, G. Lu, G. Shao
- BiologyBiochemical and Biophysical Research…
- 2014
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