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Human brain organoid-on-a-chip to model prenatal nicotine exposure.
The results suggest that nicotine exposure elicits impaired neurogenesis in early fetal brain development during gestation, which provides a promising platform to model neurodevelopmental disorders under environmental exposure, which can be extended for applications in brain disease studies and drug testing.
Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system
The generated hiPSCs-derived 3D brain organoids display well-defined neural differentiation, regionalization and cortical organization under perfused culture conditions, which recapitulate the key features of early human brain development.
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system.
The established liver organoid-on-a-chip system may provide a promising platform for engineering stem cell-based organoids with applications in regenerative medicine, disease modeling and drug testing.
Advances in Hydrogels in Organoids and Organs-on-a-Chip.
- Haitao Liu, Yaqing Wang, Kangli Cui, Y. Guo, Xu Zhang, J. Qin
- Medicine, Materials ScienceAdvanced materials
- 1 December 2019
The remarkable properties of defined hydrogel as proper extracellular matrix that can instruct cellular behaviors are presented and the recent trend where functional hydrogels are integrated into organoids and OOC systems for the construction of 3D tissue models is highlighted.
Engineering human islet organoids from iPSCs using an organ-on-chip platform.
A new strategy to engineer human islet organoids derived from human induced pluripotent stem cells (hiPSCs) using an organ-on-a-chip platform combined with stem cell developmental principles is presented, which may provide a promising platform for organoid engineering, disease modeling, drug testing and regenerative medicine.
Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip System
A biomimetic human disease model on chip that allows to recapitulate lung injury and immune responses induced by SARS‐CoV‐2 in vitro at organ level is created, providing a unique platform for COVID‐19 research and drug development.
Probing impaired neurogenesis in human brain organoids exposed to alcohol.
- Yujuan Zhu, L. Wang, +5 authors J. Qin
- Biology, MedicineIntegrative biology : quantitative biosciences…
- 11 December 2017
A human induced pluripotent stem cell (hiPSC)-based 3D brain organoid model is proposed, and the mechanisms underlying neural dysfunctions in prenatal alcohol exposure (PAE) in vitro are explored to facilitate better understanding of the various postnatal neural disorders observed in individuals with PAE.
One-Step Generation of Aqueous-Droplet-Filled Hydrogel Fibers as Organoid Carriers Using an All-in-Water Microfluidic System.
A new all-in-water microfluidic system that allows for one-step fabrication of aqueous-droplet-filled hydrogel fibers (ADHFs) with unique morphology and tunable configurations is proposed, which exhibit high controllability, uniformity, biocompatibility, and stability.
Simple Spinning of Heterogeneous Hollow Microfibers on Chip.
- Yue Yu, Wenbo Wei, Yaqing Wang, Cong Xu, Y. Guo, J. Qin
- Materials Science, MedicineAdvanced materials
- 1 August 2016
A novel and simple chip-based microfluidic strategy is proposed for continuously controlled spinning of desirable hollow microfibers that exhibit extraordinary morphological and structural complexity, as well as a heterogeneous composition.
In situ generation of human brain organoids on a micropillar array.
A simple strategy to enable in situ formation of massive brain organoids from hiPSCs on a micropillar array without tedious manual procedures is proposed and can greatly simplify brain organoid formation protocols as compared to conventional methods, overcoming the potential limitations of cell contamination, lower throughput and variance of organoid morphology.