Learn More
p300, a transcriptional co-activator with histone acetyl transferase (HAT) activity, plays an essential role in the pathogenesis of cardiomyocyte hypertrophy in response to multiple pro-hypertrophic stimuli including hyperglycemia. However, the precise mechanisms by which p300 expression is regulated remain unclear. The purpose of this study was to(More)
Predicting the popularity of Point of Interest (POI) has become increasingly crucial for location-based services, such as POI recommendation. Most of the existing methods can seldom achieve satisfactory performance due to the scarcity of POI's information, which tendentiously confines the recommendation to popular scenic spots, and ignores the unpopular(More)
The high glucose‑induced activation of protein kinase C‑β2 (PKC‑β2) has an essential role in the pathophysiology of diabetes‑associated vascular disease. In the present study, human umbilical vein endothelial cells (HUVECs) were cultured in high and normal glucose conditions prior to being infected with a recombinant adenovirus to induce the overexpression(More)
  • 1