Yaochun Shen

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The coating quality of a batch of lab-scale, sustained-release coated tablets was analysed by terahertz pulsed imaging (TPI). Terahertz radiation (2 to 120 cm(-1)) is particularly interesting for coating analysis as it has the capability to penetrate through most pharmaceutical excipients, and hence allows non-destructive coating analysis. Terahertz pulsed(More)
A novel in-line technique utilising pulsed terahertz radiation for direct measurement of the film coating thickness of individual tablets during the coating process was previously developed and demonstrated on a production-scale coater. Here, we use this technique to monitor the evolution of tablet film coating thickness and its inter-tablet variability(More)
Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on(More)
Two new polyhydroxysteroids isihippurols A (1) and B (2) were isolated from the MeOH extract of the gorgonian Isis hippuris in addition to nine known steroids namely gorgosterol, 3alpha-acetoxy-24-methyl 11beta,18; 18,20beta; 22,25-triepoxy-5alpha-furostane, hippurin-1, 22-epi-hippuristanol, 22-epi-hippurin-1, 3-acetyl-2-deacetyl-22-epi-hippurin-1,(More)
This paper focuses on the application of full-field optical coherence tomography (FF-OCT) imaging on quantifying coating thickness and characterizing coating structures of two-layer pharmaceutical pellets. This FF-OCT system used an inexpensive infrared light-emitting diode (LED) as the optical source and a commercial high speed complementary metal-oxide(More)
An optical coherence tomography-based structural vibration sensor system is reported. The system employs a halogen tungsten lamp as the low-coherence light source and a broadband CCD-based spectrometer as the detector. Unlike traditional piezoelectric accelerometer, the sensor system is non-contact and it measures the surface displacement of a sample(More)
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