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Role of the tumor microenvironment in tumor progression and the clinical applications (Review).
TLDR
The mechanisms involved in the recruitment of stromal cells by tumor cells to the primary tumor site are summarized and the role of the tumor microenvironment in the regulation of tumor progression is highlighted. Expand
Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study
Transcription factors c-Jun and Fra-1 have been reported to play a role during the initiation and progression in oral squamous cell carcinoma (OSCC). However, cohort studies are rarely reported. HereExpand
YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity
TLDR
A genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) is used to disrupt transcriptional networks for cell cycle and terminal differentiation in human keratinocytes and mouse skin. Expand
Roles of FGFR in oral carcinogenesis
TLDR
This review focuses on aberrant regulation of FGFRs in pathogenesis of oral squamous cell carcinoma (OSCC), including altered expression and subcellular location, aberrant isoform splicing and mutations. Expand
MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis
TLDR
The present study suggests that NCOA7 is a potential biomarker for early diagnosis of OSF malignant transformation, and leads to a better understanding of the molecular mechanisms responsible for OSCC development. Expand
Role of fibroblast growth factor receptor 4 in cancer
TLDR
In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized. Expand
Adoptive Induced Antigen-Specific Treg Cells Reverse Inflammation in Collagen-Induced Arthritis Mouse Model
TLDR
Findings suggest this novel approach to generate antigen-specific Treg cells by culturing CD4+ T cells from mice with RA onset may have clinical applications for treatment of autoimmunity, including RA and other autoimmune disorders. Expand
Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma
TLDR
An overview of the current status, potential strategies, and challenges of precision medicine in head and neck squamous cell carcinoma is presented and targeted therapy based on cell the surface signaling receptors epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and human Epidermal Growth factor receptor-2 (HER2) is discussed. Expand
Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis
TLDR
The present data suggest that CypA might be a potential biomarker and therapeutic target for OSF, and will lead to a better understanding of OSF pathogenesis, and a pro-proliferative property of CypA in fibroblast cells by using multiple in vitro models. Expand
LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS
TLDR
It is demonstrated that the expression of LRP6 in OSCC cells is positively correlated with its downstream oncogene, FGF8, and could be a potential biomarker for OSCC patients, and might further assist in the therapeutic decisions in OS CC treatment. Expand
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