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Protection from spoofing attacks is an essential component of speaker verification systems. This paper proposes a novel approach to detect such attacks by utilizing supervectors derived from spectral magnitude and phase information. Three countermeasures are chosen to represent these important information. To combine different countermeasures, score fusion(More)
BACKGROUND A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. METHODS AND FINDINGS We have assessed the relationship between these two(More)
Chromatin insulators are DNA elements that regulate the level of gene expression either by preventing gene silencing through the maintenance of heterochromatin boundaries or by preventing gene activation by blocking interactions between enhancers and promoters. CCCTC-binding factor (CTCF), a ubiquitously expressed 11-zinc-finger DNA-binding protein, is the(More)
Recently, the integration of deep neural networks (DNNs) with i-vector systems is proved to be effective for speaker verification. This method uses the DNN with senone outputs to produce frame alignments for sufficient statistics extraction. However, two types of data mismatch may degrade the performance of the DNN-based speaker verification systems. First,(More)
Ternary TiO2-SiO2-Ag nanocomposites with enhanced visible-light photocatalytic activity have been synthesized through a facile biomimetic approach by utilizing lysozyme as both inducing agent of TiO2 and reducing agent of Ag(+). TiO2 nanoparticles (∼280 nm) are at first fabricated by the inducing of lysozyme. Afterward, SiO2 layers are formed as "pancakes"(More)
Recently, the integration of deep neural networks (DNNs) trained to predict senone posteriors with conventional language modeling methods has been proved effective for spoken language recognition. This work extends some of the senone-based DNN frameworks by replacing the DNN with the LSTM RNN. Two of these approaches use the LSTM RNN to generate features.(More)
Pancreatic cancer (PC) is an aggressive malignancy with extremely low 5-year survival rate (<5%). SWItch/Sucrose Non Fermentable (SWI/SNF) complex is a core factor for chromatin-remodeling that utilize energy of ATP hydrolysis to mobilize nucleosomes, and modulate gene transcription. Recent studies have identified recurrent mutations in major components of(More)
BACKGROUND A recent genome-wide association study has identified a new susceptibility locus, kinesin family member 1B gene (KIF1B), strongly associated with progression from chronic hepatitis B (CHB) to hepatitis B virus-related hepatocellular carcinoma (HCC) in Chinese population, this study was carried out to explore the role of the genetic variants in(More)
As more and more complete bacterial genome sequences become available, the genome annotation of previously sequenced genomes may become quickly outdated. This is primarily due to the discovery and functional characterization of new genes. We have reannotated the recently published genome of Shewanella oneidensis with the following results: 51 new genes have(More)
Although Neurexins, which are cell adhesion molecules localized predominantly to the presynaptic terminals, are known to regulate synapse formation and synaptic transmission, their roles in the regulation of synaptic vesicle release during repetitive nerve stimulation are unknown. Here, we show that nrx mutant synapses exhibit rapid short term synaptic(More)