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Alzheimer disease (AD) is an age-dependent neurodegenerative disease characterized by the formation of β-amyloid (Aβ)-containing senile plaque. The disease could be induced by the administration of Aβ peptide, which was also known to upregulate inducible nitric oxide synthase (iNOS) and stimulate neuronal apoptosis. The present study is aimed to elucidate(More)
This study examines the effect of Propentofylline (PPF) on reactive microglia in the lumbar spinal cord in rats following focal cerebral ischaemia produced by permanent occlusion of the middle cerebral artery (MCA). Our results showed that daily treatment of PPF beginning at 24 h after MCA occlusion for 2 or 4 consecutive days markedly suppressed the(More)
This study investigated transsynaptic neuronal damage and microglial reaction in the spinal cord contralateral to focal cerebral ischaemia in rats induced by permanent occlusion of the right middle cerebral artery (MCA). Three and five days after MCA occlusion, some neurons in the dorsal horn of lumbar spinal cord underwent degeneration and they appeared to(More)
The response of microglia and astrocytes, as detected immunohistochemically by the monoclonal antibody OX-42 and anti-glial fibrillary acidic protein (GFAP) respectively, was studied in the rat lumbar spinal cord following focal cerebral ischaemia produced by permanent occlusion of the middle cerebral artery (MCA) above the rhinal fissure. At 1 and 2 days(More)
This study examined c-fos protein expression in the brain and spinal cord of rats following permanent occlusion of the middle cerebral artery (MCA) above the rhinal fissure. At 1 h after right-sided MCA occlusion, Fos-like immunoreactivity (Fos-LI) was detected in neurons not only in the ipsilateral cerebral cortex but also in the spinal cord. In the(More)
In ray-finned fishes, the lateral (Dl) and medial (Dm) division of the dorsal telencephalon are important in learning and memory formation. Tract-tracing studies revealed that neural connections are formed between these regions via afferent Dl fibers projecting to the Dm. However, research analyzing Dl-Dm synaptic transmission is scant. We have used(More)
Sepsis is characterized as an uncontrolled inflammatory response. Spite et al. (Nature 461(7268):1287–1291, 2009) had demonstrated that resolvin D2, which is derived from docosahexaenoic acid (DHA), improves survival in cecal ligation and puncture (CLP)-initiated sepsis and enhances bacterial clearance without immune suppression. Resolvin D1, which is also(More)
N-Methyl-d-aspartate (NMDA) receptors are implicated in a wide range of complex behavioral functions, including cognitive activity. Numerous studies have shown that using the repetitive administration of a noncompetitive NMDA receptor antagonist, MK-801, induces amnesia in rodents. In this study, the effect of a subchronic MK-801 treatment on the cognitive(More)
The study was aimed at the investigation of the rat corticospinal system both functionally and anatomically using as a functional marker the immediate early gene c-fos, combined with retrograde tracing with horseradish peroxidase (HRP). This was achieved by mapping c-fos induction immunocytochemically in the spinal cord as a result of occlusion of the(More)
This study is a sequel of our previous work which demonstrated the expression of Fos-like immunoreactivity (Fos-LI) in the spinal cord motoneurons of rat following permanent occlusion of the middle cerebral artery (MCA). We report here Fos-LI in the hypothalamic, medullary and thoracic spinal cord neurons some of them are believed to be involved in(More)