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BACKGROUND Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-κB activation. Celastrol induces apoptosis by means of proteasome inhibition and suppresses prostate tumor growth. However, the detailed mechanism of action(More)
BACKGROUND Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis (XIAP) and nuclear factor-kappaB function as key negative regulators of TRAIL signaling. In this study, we evaluated the effect of SH122, a(More)
Our recent studies have revealed that among the 10 different commonly used adeno-associated virus (AAV) serotypes, AAV3 vectors transduce human liver cancer cells extremely efficiently because these cells express high levels of human hepatocyte growth factor receptor (hHGFR), and AAV3 utilizes hHGFR as a cellular co-receptor for viral entry. In this report,(More)
c-Met tyrosine kinase hyperactivation is strongly associated with tumor metastasis. In a prior study we showed that BMS-777607, a novel selective small molecule Met kinase inhibitor, potently suppressed ligand-mediated functions in prostate cancer cells. Herein we evaluated the impact of this agent on the potential of the highly metastatic murine KHT(More)
The c-Met receptor tyrosine kinase is aberrantly activated in many solid tumors. In a prior study we showed that prostate cancer PC-3 cells exhibit constitutively activated c-Met without exogenous hepatocyte growth factor (HGF); however whether this characteristic is due to an endogenous HGF/c-Met autocrine loop remains controversial. In the current study(More)
For homogeneous material and non-homogeneous material plates, the crack-tip field plays an important role in the research of fracture mechanics. In this paper, the governing equations are derived. Then, the series expansion is applied to find the crack-tip field of circular plates of functionally graded materials (FGMs) with Reissner's effect. Finally, the(More)
The higher order asymptotic fields which are similar to the Williams' solutions of plane crack problems in homogenous materials are obtained by the asymptotic analysis for a crack in functionally graded Reissner's spherical shell. The results provide a theoretical basis for the numerical analysis, experimental investigation and the engineering application(More)
An Oblique anti-plane crack is studied with its tip at the physical weak-discontinuous line of the structure which is made up of homogeneous material and functionally graded materials (FGMs). The analytic solution of the higher order crack tip fields (similar to the Williams' solution of homogenous material) is obtained by applying the asymptotic series(More)
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