Yanyao Deng

  • Citations Per Year
Learn More
OBJECTIVE To investigate the presence of β-amyloid peptide (Aβ) deposition in the cerebellum and the expression of related miRNAs in the cerebellum of a mouse model of Alzheimer disease. METHODS Twelve 12-month-old APPswe/PSδE9 double transgenic mice and 12 wild-type C57 mice were sacrificed and the brain tissues were taken for examination. The right(More)
We examined the relationship between loci polymorphisms (rs689021, rs3824966, and rs1784933) of the sortilin-related receptor 1 gene (SORL1) and late-onset Alzheimer's disease (LOAD) in the Chinese Han population of the Hunan Changsha region. A case-control association analysis was used. Clinical data and peripheral blood were collected from 201 Alzheimer's(More)
MicroRNAs (miRNAs) are noncoding RNAs that are around 22 nucleotides in length. miRNAs play a key role in neuronal development, differentiation, and synaptic plasticity. An increasing amount of evidence indicates that miRNAs regulate the expression of β-site APP cleaving enzyme (BACE1), a key enzyme in Alzheimer's disease (AD) pathology. Changes in miRNA(More)
OBJECTIVE To observe the changes of miRNA expression profiles in APPswe/PSδE9 transgenic mice and explore the possible roles of miRNA in the pathogenesis of Alzheimer's disease. METHODS Using miRNA chip technique, we examined the miRNA expression in the brain tissue of 6-month-old APPswe/PSδE9 transgenic mice, with age-matched wild-type mice as the(More)
In recent years, researchers have found that adiponectin (ANP) plays an important role in the pathogenesis of Alzheimer's disease (AD), and low serum concentrations of ANP are associated with AD. Higher plasma ANP level have a protective effect against the development of cognitive decline, suggesting that ANP may affect AD onset. Meanwhile, accumulating(More)
OBJECTIVE To detect the expression of signal transducer and activator of transcription 3 (STAT3) and P-STAT3 in the brain of the APPswe/PS δE9 double transgenic mouse model of Alzhaimer's disease (AD) and investigate their possible role in AD. METHODS APPswe/PS δE9 double transgenic mice and control mice were examined for cerebral STAT3 and P-STAT3(More)
This study aimed to determine the connection between polymorphisms of kallikrein kinin system including KLK1 (rs5516), KNG1 (rs710446, rs2304456) and ACE (rs4291, rs4309, rs4343) and late-onset Alzheimer's disease (LOAD). The research was conducted as a case-control study, comprising 201 AD patients in the AD group, and 257 healthy subjects as the control(More)
OBJECTIVE To determine the association between the polymorphism of angiotensin converting enzyme (ACE) gene and Alzheimer's disease (AD). METHODS This case-control study involved 201 AD patients and 257 healthy subjects matched for age and gender as the control group. Polymerase chain reaction amplification and matrix-assisted laser desorption/ ionization(More)
The authors are listed out of order. The publisher apologizes for this error. Please view the correct author order, affiliations, and citation here: Wei Li,, Zhuling Yu, Deren Hou , Lin Zhou, Yanyao Deng, Mi Tian, Xialu Feng Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China Department of Nerve medical center, The(More)
OBJECTIVE To detect the expression of miRNA-135a-5p, miRNA-135a-2-3p, miRNA-298-5p, miRNA-466b-3p and miR-669f-3p in the brain tissue of the APPswe/PS δE9 double transgenic mouse model of Alzheimer's disease using real-time PCR. METHODS Six-month-old APPswe/PS δE9 double transgenic mice and wild-type C57 mice of the same species were examined for the(More)
  • 1