Yanyan Mao

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Sensory nerves of the brainstem are mostly composed of placode-derived neurons, neural crest-derived neurons and neural crest-derived Schwann cells. This mixed origin of cells has made it difficult to dissect interdependence for fiber guidance. Inner ear-derived neurons are known to connect to the brain after delayed loss of Schwann cells in ErbB2 mutants.(More)
OBJECTIVE We sought to study the alterations of inducible nitric oxide synthase (iNOS) in the mouse brainstem during facial paralysis induced by herpes simplex virus type 1 (HSV-1) and the inhibitory effects of glucocorticoids. METHODS HSV-1 was inoculated into the surface of posterior auricle of mouse to set up an animal model. The paralyzed mice were(More)
Conclusion C/GP hydrogel was demonstrated to be an ideal drug delivery vehicle and scaffold in the vein conduit. Combined use autologous vein and NGF continuously delivered by C/GP-NGF hydrogel can improve the recovery of facial nerve defects. Objective This study investigated the effects of chitosan-β-glycerophosphate-nerve growth factor (C/GP-NGF)(More)
Bell's palsy presents a unilateral weakness or paralysis of the face due to acute dysfunction of the peripheral facial nerve with no readily identifiable cause. Although data show that herpes simplex virus type 1 (HSV-1) may be the possible causative agent of Bell's palsy, the precise mechanism of the paralysis is still unknown. SHANK-associated RH(More)
The α2-adrenergic receptors (α2-ARs), which mediate physiological responses to noradrenaline and adrenaline, are encoded by three different genes but all are coupled to the Gi/Go subfamily of G proteins. The present study investigated the localization of three subtypes, i.e., α2a-, α2b-, and α2c-ARs, in cochlea and vestibular labyrinth in rat in the early(More)
Herpes simplex virus 1 (HSV-1) is regarded as an important underlying cause of Bell’s palsy, but the immunologic mechanism remains unknown. Here, we employed a mouse facial paralysis model to investigate the expressions of CD4+ T lymphocytes and interleukin (IL)-2 and -4 in the left draining cervical lymph nodes (LCLN) and spleen, as well as the inhibitory(More)
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