Learn More
§0. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 §1. Reductions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 498 §2. The proof of Proposition 1.4 . . . . . . . . . . . . . . . . . . . . . . . . . . . .(More)
The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For instance, it is the major source of circulating erythropoietin and renin. Despite currently available therapies, there is a marked increase in cardiovascular morbidity and mortality among patients suffering from end-stage renal disease. We hypothesized(More)
Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex. Transcriptional target analysis revealed that the LSD1/NuRD complexes regulate several cellular(More)
We will report some results concerning the Yamabe problem and the Nirenberg problem. Related topics will also be discussed. Such studies have led to new results on some conformally invariant fully nonlinear equations arising from geometry. We will also present these results which include some Liouville type theorems, Harnack type inequalities, existence and(More)
and we define Γ+k = component of {σk > 0} containing the positive cone. We also define Γ−k = −Γ + k . For a symmetric linear transformation A : V → V , where V is an n-dimensional inner product space, the notation A ∈ Γ±k will mean that the eigenvalues of A lie in the corresponding set. We note that this notation also makes sense for a symmetric tensor on a(More)
PURPOSE The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism. EXPERIMENTAL DESIGN Aldefluor assay and mammosphere formation assay(More)
The purpose of this study is to investigate the efficacy and the mechanism of Hsp90 inhibition of Withaferin A (WA), a steroidal lactone occurring in Withania somnifera, in pancreatic cancer in vitro and in vivo. Withaferin A exhibited potent antiproliferative activity against pancreatic cancer cells in vitro (with IC(50)s of 1.24, 2.93 and 2.78 microM) in(More)
The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and conformational maturation of various oncogenic proteins in cancer. The loading of protein kinases to Hsp90 is actively mediated by the cochaperone Cdc37. The crucial role of the Hsp90-Cdc37 complex has made it an exciting target for cancer treatment. In this study,(More)