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Online advertising allows advertisers to only bid and pay for measurable user responses, such as clicks on ads. As a consequence, click prediction systems are central to most online advertising systems. With over 750 million daily active users and over 1 million active advertisers, predicting clicks on Facebook ads is a challenging machine learning task. In(More)
Many problems in NLP require solving a cascade of subtasks. Traditional pipeline approaches yield to error propagation and prohibit joint training/decoding between subtasks. Existing solutions to this problem do not guarantee non-violation of hard-constraints imposed by subtasks and thus give rise to inconsistent results, especially in cases where(More)
MOTIVATION Time series expression experiments have emerged as a popular method for studying a wide range of biological systems under a variety of conditions. One advantage of such data is the ability to infer regulatory relationships using time lag analysis. However, such analysis in a single experiment may result in many false positives due to the small(More)
MOTIVATION When analyzing expression experiments, researchers are often interested in identifying the set of biological processes that are up- or down-regulated under the experimental condition studied. Current approaches, including clustering expression profiles and averaging the expression profiles of genes known to participate in specific processes, fail(More)
Methods suggested for reconstructing regulatory networks can be divided into two sets based on how the activity level of transcription factors (TFs) is inferred. The first group of methods relies on the expression levels of TFs, assuming that the activity of a TF is highly correlated with its mRNA abundance. The second treats the activity level as(More)
Array comparative genome hybridization (aCGH) data are often seriously confounded by exogenous (e.g., experimental conditions) and endogenous (i.e., DNA contents) noises, and variations of hybridization signal intensities even within each gene-dosage state. We propose a new statistical method, Genome Imbalance Scanner (GIMscan), for automatically decoding(More)
Structural genomics initiatives are leading to rapid growth in newly determined protein 3D structures, the functional characterization of which may still be inadequate. As an attempt to provide insights into the possible roles of the emerging proteins whose structures are available and/or to complement biochemical research, a variety of computational(More)
The increasing interest in supporting multiparty remote collaboration has created both opportunities and challenges for the research community. The research reported here aims to develop tools to support multiparty remote collaborations and to study human behaviors using these tools. In this paper we first introduce an experimental multimedia (video and(More)
The goal of the Facebook recommendation engine is to compare and rank heterogeneous types of content in order to find the most relevant recommendations based on user preference and page context. The challenges for such a recommendation engine include several aspects: 1) the online queries being processed are at very large scale; 2) with new content types(More)