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BACKGROUND The prediction of conformational B-cell epitopes is one of the most important goals in immunoinformatics. The solution to this problem, even if approximate, would help in designing experiments to precisely map the residues of interaction between an antigen and an antibody. Consequently, this area of research has received considerable attention(More)
Identification of epitopes which invoke strong humoral responses is an essential issue in the field of immunology. Localizing epitopes by experimental methods is expensive in terms of time, cost, and effort; therefore, computational methods feature for its low cost and high speed was employed to predict B-cell epitopes. In this paper, we review the recent(More)
Epitope prediction based on random peptide library screening has become a focus as a promising method in immunoinformatics research. Some novel software and web-based servers have been proposed in recent years and have succeeded in given test cases. However, since the number of available mimotopes with the relevant structure of template-target complex is(More)
Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) are multifunctional cytokines that regulate immune responses, cell proliferation, and tumour development and progression, which frequently have functionally opposing roles. The cellular responses to both cytokines are activated via the Janus kinase/signal transducer and activator of transcription(More)
In this paper, a novel quantum swarm evolutionary algorithm (QSE) is presented based on the quantum-inspired evolutionary algorithm (QEA). A new definition of Q-bit expression called quantum angle is proposed, and an improved particle swarm optimization (PSO) is employed to update the quantum angles automatically. The simulated results in solving 0–1(More)
The performance of support vector machines (SVM) drops significantly while facing imbalanced datasets, though it has been extensively studied and has shown remarkable success in many applications. Some researchers have pointed out that it is difficult to avoid such decrease when trying to improve the efficient of SVM on imbalanced datasets by modifying the(More)
The transcriptional regulation of gene expression is a key mechanism in the functioning of the cell. It is mostly affected through acting element binding to specific sequence motifs. In this paper, we present a computational based approach to select the most relevant information for searching binding motifs from the long upstream regions. First, we(More)