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Influenza A (H1N1) can cause severe neurological complications. The purpose of this study was to analyze clinical and MRI features of neurological complications after H1N1 infection in critically ill children. We retrospectively analyzed clinical and neuroimaging findings in 17 children who were hospitalized in an intensive care unit with severe(More)
OBJECTIVES During the winter outbreak of 2009 influenza A (H1N1) infection in China, the number of confirmed cases and the fatal cases has grown rapidly. We describe the clinical characteristics of hospitalized children with 2009 influenza A (H1N1) infection in Shenzhen, China, November-December 2009. METHODS Using a standardized form, we collected data(More)
OBJECTIVE Sepsis is the major cause of death in pediatric intensive care unit (PICU). The clinical manifestations of early sepsis is very similar to systemic inflammatory response syndrome (SIRS) caused by non-infectious reason. This study aimed to investigate the expression of miRNA and inflammatory cytokines in plasma in pediatric sepsis patients and its(More)
OBJECTIVES This study aims to elucidate the role of breastfeeding on vertical transmission of HCMV and HBV and to investigate the difference in perinatal transmission via breast milk between HBV and HCMV. METHODS This detailed study monitored the kinetics of viral DNA load in maternal milk for both HBV and HCMV, demonstrated the rate of transmission to(More)
OBJECTIVE To analyze the factors that influence the outcome of ventilator weaning and the predictive value of ventilator weaning criteria such as PaO2/FiO2, Vt/kg, Cst, RSBI and the changing trend of RSBI [ΔRSBI = (RSBI2-RSBI1)/RSBI1, RSBI1 and RSBI2 are the start and end of SBT separately] in children. METHOD One hundred and thirty-two children who were(More)
OBJECTIVE To assess the ability of non-invasive ultrasonic cardiac output monitor (USCOM) combined with passive leg raising (PLR) test to predict volume responsiveness in septic shock children with spontaneous respiration. METHODS Prospective and observational cohort study was performed in 40 septic shock children with spontaneous breathing admitted to(More)
Hand, foot, and mouth disease (HFMD) affects more than one million children, is responsible for several hundred child deaths every year in China and is the cause of widespread concerns in society. Only a small fraction of HFMD cases will develop further into severe HFMD with neurologic complications. A timely and accurate diagnosis of severe HFMD is(More)
BACKGROUND To report the diversity of MRI features of brainstem encephalitis (BE) induced by Enterovirus 71. This is supported by implementation and testing of our new classification scheme in order to improve the diagnostic level on this specific disease. METHODS Neuroimaging of 91 pediatric patients who got EV71 related BE were hospitalized between(More)
Legionnaires' disease, a kind of systemic disease with pneumonia as the main manifestation, is caused by Legionella pneumophila (L. pneumophila). In order to prevent the disease, we optimized Mip and FlaA, the virulence factors of L. pneumophila, to design recombinant Mip-FlaA dominant epitope vaccine against the pathogen. Firstly, the coding sequences of(More)
OBJECTIVE To analyze the clinical characteristics of negative pressure pulmonary edema (NPPE). METHOD A retrospective investigation of the clinical manifestation, imageology, clinical course and outcome of 4 children with NPPE seen between June 2012 and July 2013 in a children's hospital. The causation of the airway obstruction was also explored. RESULT(More)