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Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice.
Borapetoside E showed beneficial effects in vivo, demonstrating that borapetside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.
The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake
- F. Wang, Xiaoyan Yang, Wenyong Xiong
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 May 2019
It is concluded that a natural product, antroalbol H, isolated from the basidiomycete mushroom Antrodiella albocinnamomea, increases cellular glucose uptake in murine L6 myotubes and 3T3-L1 adipocytes and therefore has potential for managing hyperglycemia.
Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging
- Qiuyan Yan, Yanting Lu, Hongda Wang
- BiologyProceedings of the National Academy of Sciences
- 18 June 2018
This work characterized the clustering distribution of GLUT1 and linked its spatial structural organization to the functions, which would provide insights into the activation mechanism of the transporter.
AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21
- Pianchou Gongpan, Yanting Lu, F. Wang, Yuhui Xu, Wenyong Xiong
- Biology, ChemistryCell cycle
- 6 May 2016
It is demonstrated that AS160 regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle, and thereby revealed a molecular mechanism of AS160 modulation of cell cycle and proliferation that is of general physiological significance.
Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS
It is demonstrated that adenanthin inhibited adipogenesis of 3T3-L1 and mouse embryonic fibroblasts, and the underlying mechanism included a delayed mitotic clonal expansion via G0/G1 cell cycle arrest by inhibiting the RB-E2F1 signaling pathway.
A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells
- Yanting Lu, Xiuli Ma, Wen-Yong Xiong
- Biology, ChemistryNatural Products and Bioprospecting
- 1 November 2018
The nonradioactive microplate and microscope-based high-throughput screening assay for measuring glucose can be a new method for screening of SGLT2 inhibitors and implied for other cell assays for glucose measurement extensively.
Pyrocincholic acid 3β-O-β-d-quinovopyranosyl-28-O-β-d-glucopyranoside suppresses adipogenesis and regulates lipid metabolism in 3T3-L1 adipocytes
PAQG inhibits the differentiation and regulates lipid metabolism of 3T3-L1 cells via AMPK pathway, suggesting that PAQG may be a novel and promising natural product for the treatment of obesity and hyperlipidemia.