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N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms

• Yanmei Zhang, Gaoyong Chen, +10 authors Ganggang Shi
• Oxidative medicine and cellular longevity
• 2013

N-n-butyl haloperidol iodide (F2) has been shown to antagonize myocardial ischemia/reperfusion injury by blocking calcium channels. This study explores the biological functions of ERK pathway in… (More)

The protective effects of Egr-1 antisense oligodeoxyribonucleotide on cardiac microvascular endothelial injury induced by hypoxia-reoxygenation.

• Yanqiong Zhou, Ganggang Shi, +6 authors Yanshan Zheng
• Biochemistry and cell biology = Biochimie et…
• 2010

Early growth response 1 (Egr-1) over-expression has been demonstrated in myocardial ischemia-reperfusion injury, which is closely associated with endothelial dysfunction. In the present study we… (More)

Baicalein suppresses the SOS response system of Staphylococcus aureus induced by ciprofloxacin.

• Qing Peng, Shuqin Zhou, +5 authors Yuanshu Qian
• Cellular physiology and biochemistry…
• 2011

Numerous antibiotics can induce an SOS repair system in bacteria that leads to antibiotic-resistant mutation of the bacterium. Therefore, searching for drugs that can prevent the SOS response and… (More)

Induction of monocyte chemoattractant protein-1 release from A549 cells by agonists of protease-activated receptor-1 and -2.

• Haiyan Wang, Tingting Yi, Yanshan Zheng, Shao-heng He
• European journal of cell biology
• 2007

Hypersecretion of cytokines and serine proteases has been observed in asthma. However, the influence of proteases and protease-activated receptors (PARs) on monocyte chemoattractant protein-1 (MCP-1)… (More)

Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism.

• Huiyun Zhang, Junling Wang, +6 authors Shaoheng He
• British journal of pharmacology
• 2018

BACKGROUND AND PURPOSE Chymase is a unique, abundant secretory product of mast cells and a potent chemoattractant for eosinophils, monocytes and neutrophils, but little is known of its influence on… (More)

Expression of proteinase-activated receptor (PAR)-2 in monocytes from allergic patients and potential molecular mechanism

• Shuqing Ge, Tao Li, +5 authors Shao-heng He
• Cell Biology and Toxicology
• 2016

Serine proteases play an important role in inflammation via PARs. However, little is known of expression levels of PARs on monocytes of allergic patients, and influence of serine proteases and PARs… (More)

Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases

• Haiyan Wang, Yanshan Zheng, Shao-heng He
• BMC Cell Biology
• 2005

Hypersecretion of cytokines and serine proteinases has been observed in asthma. Since protease-activated receptors (PARs) are receptors of several serine proteinases and airway epithelial cells are a… (More)

N-n-Butyl haloperidol iodide inhibits the augmented Na+/Ca2+ exchanger currents and L-type Ca2+ current induced by hypoxia/reoxygenation or H2O2 in cardiomyocytes.

• Yongpan Huang, Fenfei Gao, +4 authors Ganggang Shi
• Biochemical and biophysical research…
• 2012

N-n-butyl haloperidol iodide (F(2)), a novel quaternary ammonium salt derivative of haloperidol, was reported to antagonize myocardial ischemia/reperfusion injuries. To investigate its mechanisms, we… (More)

Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.

• Huiyun Zhang, Xiaoyu Yang, +6 authors Shao-heng He
• Immunology and cell biology
• 2007

It has been recognized that protease-activated receptors (PARs), interleukin (IL)-4 and IL-6 are involved in the pathogenesis of allergic diseases, and that IL-12 plays a role in adaptive immune… (More)

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