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Structure and regulation of the vacuolar ATPases.
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
TLDR
The evidence that the pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation, is provided.
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis
TLDR
H3K9me2 level was elevated in the promoter region of the rDNA gene inPHF8 knockdown cells and reduced significantly when the wild type but not the catalytically inactive H247A mutant PHF8 was overexpressed, indicating a histone demethylase for H3K 9me2 that regulates rRNA transcription.
MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects.
TLDR
E(2) regulates miRNA expression in an age- and E(2)-dependent manner, which results in differential gene expression and consequently altered neuronal function, which is hypothesized to lead to increased risks for cognitive disorders.
Subunit a of the Yeast V-ATPase Participates in Binding of Bafilomycin*
TLDR
Results suggest that subunit a of V-ATPase participates along with subunit c in binding bafilomycin, a region similar to that shown to participate in oligomycin binding by the F- ATPase.
Analysis of the Membrane Topology of Transmembrane Segments in the C-terminal Hydrophobic Domain of the Yeast Vacuolar ATPase Subunit a (Vph1p) by Chemical Modification*
TLDR
The results support an eight transmembrane helix (TM) model of subunit a in which the C terminus is located on the cytoplasmic side of the membrane and provide information on the location of hydrophilic loops separating TM6, 7, and 8.
Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking*
TLDR
The findings indicate that HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells, and may facilitate tumor growth and cancer progression.
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis
TLDR
A critical interaction of these two lipid metabolism pathways on tumorigenesis is demonstrated and dual inhibition of COX-2 and sEH is suggested as a potential therapeutic strategy for cancer therapy.
Duct system of the rabbit lacrimal gland: structural characteristics and role in lacrimal secretion.
TLDR
The present data establish a nomenclature for each segment of the Lacrimal duct system and provide evidence that ducts play critical roles in lacrimal secretion.
The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation
TLDR
Cysteine-mediated cross-linking has been used to localize subunit isoforms within the V-ATPase complex and to investigate the helical interactions between subunits within the integral V0 domain.
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