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CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
A gene CREPT is reported that is preferentially expressed in diverse human tumors and a mechanism where CREPT increases cyclin D1 transcription during tumorigenesis is revealed, through enhancing the recruitment of RNAPII to the promoter region, possibly as well as chromatin looping. Expand
RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.
RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/β-catenin pathway in colorectal carcinogenesis, demonstrating that RNF6 plays a pivotal oncogenic role in colOREctal tumorigenesis. Expand
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
The pathway by which squalene epoxidase promotes the development of hepatocellular carcinoma is examined and terbinafine, a clinically approved antifungal drug, is identified as a potential intervention to prevent and treat NAFLD-HCC. Expand
GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway
It is suggested that GABARAPL1 as a tumor repressor inhibits Wnt signaling via mediating Dvl2 degradation through the autophagy pathway. Expand
Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation.
It is found that overexpression of Rab21 attenuated EGF-mediated mitogen-activated protein kinase (MAPK) signaling by inducing EGFR degradation, suggesting that Rab21 plays a negative role in the E GF-mediated MAPK signaling pathway. Expand
Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A
ZNF471 acts as a tumor suppressor in gastric cancer by transcriptionally inhibiting downstream targets TFAP2A and PLS3 and recruit KAP1, a co-repressor of ZNF471 at the promoter of the target genes, thereby inducing H3K9me3 enrichment for transcriptional repression and inhibition of oncogenic TFAP1 and P LS3. Expand
p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand
CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling*
The study suggests that CREPT acts as an activator to promote transcriptional activity of the β-catenin·TCF4 complex in response to Wnt signaling, which results in up-regulated cell proliferation and invasion. Expand
Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC)
Results indicate that simvastatin enhances the efficacy of enzalutamide-based therapy, highlighting the therapeutic potential of statins to overcome enzalUTamide resistance in CRPC. Expand
Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.
FoxF2-mediated upregulation of the E3 ligase IRF2BPL drives ubiquitylation and degradation of β-catenin in gastric cancer, blunting Wnt signaling and suppressing carcinogenesis. Expand