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miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer.

BACKGROUND AND OBJECTIVE Our previous studies reported that miR-451 could protect against erythroid oxidant stress target gene-Ywhaz (14-3-3zeta) via inhibiting FoxO3 in the erythropoiesis. This…
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Shlnc‐EC6 regulates murine erythroid enucleation by Rac1‐PIP5K pathway

This study found that knockdown of shlnc‐EC6 in purified mouse fetal liver erythroid progenitor and hematopoietic stem cells (FLEPHSCs) significantly blocked erythyroid enucleation, and suggested that shl NC6 acts as a novel modulator to regulate mouse erythropoiesis via Rac1/PIP5K signaling pathway.
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miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

The findings suggest that miR-144/451 is a key protector of erythroblasts during pathological states associated with dramatically increased erythropoietic demand, including acute blood loss and hemolytic anemia.
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Transcribed ultraconserved noncoding RNA uc.160 acts as a negative regulator in gastric cancer.

UCT.160 is significantly down-regulated in gastric carcinomas and can inhibit the tumor growth both in vitro and in vivo, suggesting that uc.160 may be used as a diagnostic marker and therapeutic target of gastric malignancies.
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Lycium barbarum Polysaccharide Promotes Nigrostriatal Dopamine Function by Modulating PTEN/AKT/mTOR Pathway in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Murine Model of Parkinson’s Disease

Results suggest that LBP can effectively alleviate the degeneration in the nigrostriatal system induced by MPTP treatment, and may be a potential candidate for the treatment of Parkinson’s disease.
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Activating and sustaining c-Myc by depletion of miR-144/451 gene locus contributes to B-lymphomagenesis

It is shown that targeted depletion of a well-conserved microRNA gene locus miR-144/451 initiates tumorigenesis including B-lymphoma development in aged mice and provides strong evidence, for the first time, that deficiency of miR/451 expression may play a bona fide role in derepression of silenced c-Myc, which contributes to tumor development including B/lymphomagenesis.
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Dietary miR-451 protects erythroid cells from oxidative stress via increasing the activity of Foxo3 pathway

It is concluded that some miRNAs in food can pass through the gastrointestinal tract into the blood to affect consumers’ function and microRNA knockout animals such as miR-144/451 null mice can acquire the deleted genetic information from daily foods, which might alter the results and conclusions from the studies using such animals.
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The synergistic antitumor activity of arsenic trioxide and vitamin K2 in HL-60 cells involves increased ROS generation and regulation of the ROS-dependent MAPK signaling pathway.

The results suggest that ATO and VK2 act synergistically to increase HL-60 cell apoptosis, through ROS generation and regulation of the MAPK signaling pathway.
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Dual effect of LPS on murine myeloid leukemia cells: Pro-proliferation and anti-proliferation.

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Lycium barbarum Polysaccharide Promotes Nigrostriatal Dopamine Function by Modulating PTEN/AKT/mTOR Pathway in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Murine Model of Parkinson’s Disease

Results suggest that LBP can effectively alleviate the degeneration in the nigrostriatal system induced by MPTP treatment, and may be a potential candidate for the treatment of Parkinson’s disease.
View on Springer (opens in a new tab)
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