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BACKGROUND The Food- Frequency Questionnaire (FFQ) is a dietary assessment tool frequently used in large-scale nutritional epidemiology studies. The goal of the present study is to validate a self-administered version of the Hawaii FFQ modified for use in the general adult population of Newfoundland and Labrador (NL). METHODS Over a one year period, 195(More)
OBJECTIVE Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the(More)
BACKGROUND Body adiposity index (BAI), indirect method proposed to predict adiposity, was developed using Mexican Americans and very little data are available regarding its validation in Caucasian populations to date. OBJECTIVE The study objectives were to validate the BAI with dual-energy X-ray absorptiometry (DXA) body fat percentage (%BF), taking into(More)
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the relationship between dietary Se and obesity, and findings are inconsistent. We aimed to investigate the association between(More)
BACKGROUND Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity. OBJECTIVE The present study investigated the response of circulating acylated ghrelin to a 7-day positive energy challenge. (More)
BACKGROUND Glucagon-like Peptide-1 (GLP-1) is an incretin hormone secreted from the gastrointestinal tract that facilitates the glucose-dependent insulin response. Additionally, GLP-1 is thought to be involved in energy homeostasis. Currently little is known about GLP-1's responsiveness to an energy surplus, a fundamental cause of obesity and diabetes. Our(More)
BACKGROUND Ghrelin and peptide YY (PYY) are appetite regulating hormones secreted from the gastrointestinal tract (gut). Aside from their known effect on energy homeostasis, accumulating data indicates that these gut hormones also affect bone metabolism. However, data regarding the influence of ghrelin and PYY on bone density in humans is very limited, and(More)
Data collected from response adaptive designs are dependent. Traditional statistical methods need to be justified for the use in response adaptive designs. This paper generalizes the Rao’s score test to response adaptive designs and introduces a generalized score statistic. Simulation is conducted to compare the statistical powers of the Wald, the score,(More)
BACKGROUND Adequate dietary intake is essential to maintain good health. This is particularly true for the elderly. This study investigated the dietary intakes of seniors residing in Newfoundland and Labrador (NL) and assessed the adequacy of nutrients which they consumed as food. METHODS Between November 2012 and January 2013, we recruited senior(More)
We consider a response adaptive design of clinical trials with a variance-penalized criterion. It is shown that this criterion evaluates the performance of a response adaptive design based on both the number of patients assigned to the better treatment and the power of the statistical test. A new proportion of treatment allocation is proposed and the doubly(More)