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Industry is building larger, more complex, manycore processors on the back of strong institutional knowledge, but academic projects face difficulties in replicating that scale. To alleviate these difficulties and to develop and share knowledge, the community needs open architecture frameworks for simulation, synthesis, and software exploration which support(More)
Businesses and Academics are increasingly turning to Infrastructure as a Service (IaaS) Clouds such as Amazon's Elastic Compute Cloud (EC2) to fulfill their computing needs. Unfortunately, current IaaS systems provide a severely restricted pallet of rentable computing options which do not optimally fit the workloads that they are executing. We address this(More)
We introduce a technique for augmenting neural text-to-speech (TTS) with lowdimensional trainable speaker embeddings to generate different voices from a single model. As a starting point, we show improvements over the two state-ofthe-art approaches for single-speaker neural TTS: Deep Voice 1 and Tacotron. We introduce Deep Voice 2, which is based on a(More)
Juvenile hormone (JH) and methyl farnesoate (MF) play essential roles in the development and reproduction of insects and crustaceans respectively. Juvenile hormone acid methyltransferase (JHAMT) catalyzes the methyl esterification in insect JH biosynthesis, while the corresponding step in crustacean MF biosynthesis was long thought to be catalyzed by(More)
Memory bandwidth severely limits the scalability and performance of multicore and manycore systems. Application performance can be very sensitive to both the delivered memory bandwidth and latency. In multicore systems, a memory channel is usually shared by multiple cores. Having the ability to precisely provision, schedule, and isolate memory bandwidth and(More)
Infrastructure as a Service (IaaS) Clouds have grown increasingly important. Recent architecture designs support IaaS providers through fine-grain configurability, allowing providers to orchestrate low-level resource usage. Little work, however, has been devoted to supporting IaaS customers who must determine how to use such fine-grain configurable(More)
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies. Platinum-based chemotherapy is the first-line treatment for the advanced ovarian cancer, but resistance to cisplatin remains a major obstacle to successful treatment. MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in disease processes,(More)
......Datacenters are expanding rapidly, fueled by cloud computing and the insatiable need for server computing power to drive web-hosted services. The conventional architecture of such large-scale systems is relatively hierarchical and rigid, with boundaries between chips, boards, nodes, and racks, and it follows a scale-out approach. Piton is a manycore(More)
Data structures for non-volatile memories have to be designed such that they can be atomically modified using transactions. Existing atomicity methods require data to be copied in the critical path which significantly increases the latency of transactions. These overheads are further amplified for transactions on byte-addressable persistent memories where(More)
Emerging non-volatile memories (NVMs) like batterybacked DRAM and phase-change memory offer durability at higher speeds than traditional storage. Each technology represents a different point in the cost, performance and endurance space. In this paper, we propose that storage intensive applications use more than one kind of NVM in configurable proportions to(More)