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In this paper we present analytical studies of three-dimensional viscous and inviscid simplified Bardina turbulence models with periodic boundary conditions. The global existence and uniqueness of weak solutions to the viscous model has already been established by Layton and Lewandowski. However, we prove here the global well-posedness of this model for(More)
BACKGROUND/AIMS Nuclear factor erythroid 2-related factor 2 (Nrf2) is a positive regulator of the expression of antioxidant genes. This study is aimed at examining the effect of tert-butylhydroquinone (tBHQ), an activator of Nrf2, on hyperglycemia-related diabetic nephropathy. METHODS CD-1 mice were induced with streptozotocin and treated with 1% tBHQ, or(More)
Wrinkling of thin stiff films on thick compliant elastomeric substrates subject to plane strain compression is considered for cases in which the substrate is pre-stretched prior to film attachment. Advanced wrinkling modes are investigated that evolve as the systems are compressed beyond the onset of the primary sinusoidal wrinkling mode. If the substrate(More)
Compression of a stiff film on a soft substrate may lead to surface wrinkling when the compressive strain reaches a critical value. Further compression may cause a wrinkling-folding transition, and the sinusoidal wrinkling mode can then give way to a period-doubling bifurcation. The onset of the primary bifurcation has been well understood, but a(More)
Podocytes are terminally differentiated epithelial cells lacking the ability to proliferate. The loss of podocytes is a hallmark of progressive kidney diseases, including diabetic nephropathy (DN). Endoplasmic reticulum stress (ERS)-induced apoptosis is involved in a number of pathological conditions, including DN. The aim of the present study was to(More)
Drought is a complex natural hazard which can have negative effects on agriculture, economy, and human life. In this paper, the primary goal is to explore the application of the Gravity Recovery and Climate Experiment (GRACE) gravity satellite data for the quantitative investigation of the recent drought dynamic over the arid land of northwestern China, a(More)
Jing Wang*, Xiaoping Yuan, Baoguo Sun and Yanping Cao College of Chemistry and Environment Engineering, Beijing Technology and Business University, 11 Fucheng Road, CN-100048 Beijing, PR China Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology and Business University, 11 Fucheng Road, CN-100048(More)
Reactive oxygen species (ROS) play an important role in the pathogenesis of diabetic nephropathy. Nuclear factor erythroid 2-related factor 2 (Nrf2) can up-regulate the expression of antioxidant genes and protect cells from oxidative damage. The current study is aimed at examining the effect of modulation of Nrf2 expression on high glucose-induced oxidative(More)
BACKGROUND/AIMS Tubular epithelial cell-myofibroblast transdifferentiation (TEMT) can be induced by diverse cytokines. The suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling. This study is aimed at examining the role of SOCS-1 and SOCS-3 in TEMT induced by cytokines. METHODS The cell ultrastructure was observed using(More)