A cytotoxic T lymphocyte (CTL) clone was derived from a tumor-infiltrating lymphocyte (TIL) population infused to a melanoma patient who remained relapse free for 10 yr after this adoptive transfer. This clone recognized all melanoma cell lines tested and, to a lower extent, melanocytes, in the context of human histocompatibility leukocyte antigen A2… (More)
BACKGROUND There are several reports demonstrating the role of CD8 T cells against Leishmania species. Therefore peptide vaccine might represent an effective approach to control the infection. We developed a rational polytope-DNA construct encoding immunogenic HLA-A2 restricted peptides and validated the processing and presentation of encoded epitopes in a… (More)
BACKGROUND Double positive (DP) CD4CD8 Talphabeta cells have been reported in normal individuals as well as in different pathological conditions including inflammatory diseases, viral infections and cancer, but their function remains to be elucidated. We recently reported the increased frequency of DP Talphabeta cells in human breast pleural effusions. This… (More)
Nowadays, immunotherapy represents one promising approach for cancer treatment. Recently, spectacular results of cancer immunotherapy clinical trials have confirmed the crucial role of immune system in cancer regression. Therapeutic cancer vaccine represents one widely used immunotherapy strategy to stimulate tumor specific T cell responses but clinical… (More)
According to the cancer immunoedit-ing hypothesis, tumor cells—at least ini-tially—are immunogenic and the adaptive immune system is involved in their active elimination. 1 Among the immune cells that participate in this process, CD4 + helper T cells seem to play a major role in the generation and maintenance of effective antitu-mor immunity. 2 Thus, in… (More)
Background: Double positive (DP) CD4CD8 Tab cells have been reported in normal individuals as well as in different pathological conditions including inflammatory diseases, viral infections and cancer, but their function remains to be elucidated. We recently reported the increased frequency of DP Tab cells in human breast pleural effusions. This manuscript… (More)
[This corrects the article DOI: 10.1186/s40164-016-0036-3.].
Recent advances indicate that adaptive immune responses play a critical role in cancer immunosurveillance. Among various cell types involved in adaptive immunity, CD4 + helper T-cell subpopu-lations are critical for antitumor immune response. 1 In particular, tumor-reactive CD4 + T helper 1 cells (T H 1) produce cytokines such as interferon γ (IFNγ), tumor… (More)