Yann Clément

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Anxiety is a complex psychological and behavioural trait, related to behavioural responses as different as seizures, memory, impulsivity or aggression. The biological bases analysed in the present article involve neurotransmitter systems, specific regions in the brain and genetic factors. The genetic approach is given special emphasis as it offers, in(More)
Glutamate excitotoxicity has been involved in the pathophysiology of epilepsy. Normal functioning of glutamate transporters clears the synaptically released glutamate to prevent excitotoxic neuronal death. Using densitometric immunohistochemical analysis, we examined the temporal expression of the neuronal glutamate transporter (EAAC1) in the(More)
beta-Carbolines, such as methyl beta-carboline-3-carboxylate (beta-CCM), attach to the benzodiazepine receptors in the brain, but have effects completely opposite to those of benzodiazepines: beta-CCM is a convulsant at high doses, an anxiogenic at moderate doses, and enhances learning at low doses. The aim of this work was to detect some of the chromosomal(More)
The convulsant properties of methyl beta-carboline-3-carboxylate (beta-CCM) were evaluated in the TaT-fm/GncTa+/+Tfm strain carrying the tabby coat color (Ta) and/or the testicular feminization (Tfm) gene. When injected intraperitoneally within a 5-60 mg/kg dose range, beta-CCM-induced convulsions in less than 25% of the mice, thus providing evidence for a(More)
We studied the reactions of mice when placed in an open-field environment and counted the grooming score in response to novelty. We used animals from Mendelian F2s and backcrosses, obtained from the parental strains ABP/Le and C57BL/6By, to test the hypothesis that the differences in this behavior were due to genetic variation at loci associated with(More)
The propensity for anxiety-related behavior has been studied by comparing two highly inbred strains of mice, ABP/Le and C57BL/6ByJ, in two behavioral procedures, open-field and light-dark preference. Their Mendelian F2 population allowed us to evaluate the putative involvement of four easily identifiable loci in anxiogenic processes. In fact, chromosomal(More)
Reactivity to a new environment was studied in mice, using an open-field procedure in two strains, C57BL/6By and ABP/Le, the F1 populations and the intercrosses F2 and backcross segregating populations. The analysis of the behavioral traits: peripheral and central activities, leaning, rearing and defecation in the parental strains made it possible to show(More)
Analysis of beta-CCM induced seizures in three inbred strains of mice, ABP/Le, C57BL/6J and C57BL/6ByJ, and their F1s and F2s progeny, allowed identification of a putative seizure susceptibility controlling locus on chromosome 9 near the short-ear locus. The involvement of a gene in the medial segment of this chromosome in both seizure activity and(More)
The gamma-aminobutyric acidA (GABAA) receptor is a complex hetero-oligomeric protein. It is composed of several subunits which assemble to form a functional chloride channel. The precise molecular organization of the receptor is as yet unknown. In the first part, we review recent literature dealing with the molecular and pharmacological aspects of the GABAA(More)
The gabra5 gene is associated with pharmacological properties (myorelaxant, amnesic, anxiolytic) of benzodiazepines. It is tightly located (0.5 cM) close to the pink-eyed dilution (p) locus which encodes for fur color on mouse chromosome 7. We tested the putative role of the gabra5 gene in pharmacological properties of the full non specific agonist(More)