• Publications
  • Influence
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease
Fructose is a major component of dietary sugar and its overconsumption exacerbates key pathological features of metabolic syndrome. The central fructose-metabolising enzyme is ketohexokinase (KHK),Expand
  • 82
  • 6
jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data
TLDR
We present a novel junction-centric method, jSplice, that enables de novo extraction of alternative splicing events from RNA-sequencing data with high accuracy, reliability and speed. Expand
  • 11
  • 2
Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer
Purpose To define robust miRNA-based molecular classifiers for human clear cell renal cell carcinoma (ccRCC) subgrouping and prognostication. Experimental design Multidimensional data of over 500Expand
  • 36
  • 1
  • PDF
miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation.
Chromosomal instability enables tumor development, enabled in part by aberrant expression of the mitotic checkpoint protein Mad2. Here we identify a novel regulatory mechanism for Mad2 expressionExpand
  • 35
  • 1
  • PDF
Tissue-Plasma TMB Comparison and Plasma TMB Monitoring in Patients With Metastatic Non-small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors
Immuno-oncology is an ever growing field that has seen important progress across the spectrum of cancers. Responses can be deep and durable. However, as only a minority of patients respond toExpand
  • 7
  • 1
Gene Expression Data Analysis Using a Novel Approach to Biclustering Combining Discrete and Continuous Data
TLDR
We use the results of biclustering on discrete data as a starting point for a local search function on continuous data, our algorithm avoids the problem of heuristic initialization. Expand
  • 14
Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1
Chaperone dependency of cancer cells is an emerging trait that relates to the need of transformed cells to cope with the various stresses associated with the malignant state. URI1 (unconventionalExpand
  • 10
  • PDF
Inferring transcript phylogenies
TLDR
In this paper, we present a model of transcript evolution and an associated algorithm to reconstruct transcript phylogenies. Expand
  • 18
  • PDF
A Transcript Perspective on Evolution
TLDR
We present a framework for transcript phylogenies where ancestral transcripts evolve along the gene tree by gains, losses, and mutation. Expand
  • 6
  • PDF
BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly
Despite the great success of small molecule inhibitors in the treatment of patients with BRAFV600E mutated melanoma, the response to these drugs remains transient and patients eventually relapseExpand
  • 6
...
1
2
3
...