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PURPOSE To test the association of the X-chromosome regions (Xp21.1-q21.2 and Xq25-27.2) with Leber hereditary optic neuropathy (LHON) in Chinese patients. METHODS One hundred and seventy-five male LHON patients with the G11778A mutation and 100 unrelated normal males participated. Twelve microsatellite markers and four single-nucleotide polymorphisms(More)
PURPOSE Hepatoma-derived growth factor (HDGF) is a mitogen that promotes endothelial proliferation and neuronal survival. Using a unique technology of ligandomics, we recently identified HDGF as a retinal endothelial binding protein. The purpose of this study is to examine the role of HDGF in regulating ocular vasculature and the expression of HDGF in the(More)
Glucagon-like peptide-1 (GLP-1) reduces blood glucose and improves abnormal metabolism caused by hyperglycemia. The formation of thrombus, one of major consequences suffered from diabetes, can be inhibited by the treatment of Hirudin (HV). This study was aimed to develop a fusion peptide which combines functions of GLP-1 and HV to treat diabetes and its(More)
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