Yanli He

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Andrew C. Chang2
Wei Liu2
2Andrew C. Chang
2Wei Liu
2Jine Zheng
2Zhuwen Wang
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Pingyangmycin is an anticancer drug known as bleomycin A5 (A5), discovered in the Pingyang County of Zhejiang Province of China. Bleomycin (BLM) is a mixture of mainly two compounds (A2 and B2), which is on the World Health Organization's list of essential medicines. Both BLM and A5 are hydrophilic molecules that depend on transporters or endocytosis(More)
We employed next generation RNA sequencing analysis to reveal dysregulated long non-coding RNAs (lncRNAs) in lung cancer utilizing 461 lung adenocarcinomas (LUAD) and 156 normal lung tissues from 3 separate institutions. We identified 281 lncRNAs with significant differential-expression between LUAD and normal lung tissue. LINC00857, a top deregulated(More)
Interleukin-3 (IL-3) receptor α chain (CD123) plays an essential role in regulating the proliferation of hematopoietic stem cells. In the hematopoietic malignancies, CD123 expression has been found in acute myeloid leukemia (AML), B-precursor acute lymphoblastic leukemia (B-ALL), as well as dendritic cell malignancies. However, whether CD123 is also(More)
MAP3K3 is involved in both the immune response and in tumor progression. Its potential biological role in vitro in lung cancer cell lines and the association of mRNA/protein expression patterns with clinical outcome of primary lung tumors were investigated in this study. Silencing MAP3K3 using siRNA in lung cancer cell lines resulted in decreased cell(More)
Acute promyelocytic leukemia (APL) is a specific malignant hematological disorder with a diagnostic hallmark of chromosome translocation t(15;17)(q22;q21). As a very rare secondary cytogenetic aberration in pediatric APL, ider(17q) (q10)t(15;17) was suggested to be a poor prognostic factor based on previous case reports.Here, we report a pediatric APL case(More)
Apical necrosis is a widely distributed disease in the culture of the marine agar-producing alga, Gracilariopsis lemaneiformis. In this study, 16 strains of epiphytic bacteria were isolated from the tip bleaching parts of G. lemaneiformis; of the 16 strains, two strains could induce healthy algal tips to become necrotic. They were identified as(More)
Manufacturing automation with adoptability to the changing environment is a competitive advantage for shop floors. This paper presents a flexible workflow enacted job shop manufacturing execution and automation system. The manufacturing process sequence of each part is modeled as an abstract workflow and each manufacturing job resulting in a batch of the(More)
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