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Validation of Copy Number Variation Sequencing for Detecting Chromosome Imbalances in Human Preimplantation Embryos1
ABSTRACT Chromosome aneuploidies commonly arise in embryos produced by assisted reproductive technologies and represent a major cause of implantation failure and miscarriage. Currently,Expand
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Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice
Aims/hypothesisThe aim of the study was to investigate the effects of genetic deficiency of aldose reductase in mice on the development of key endpoints of diabetic nephropathy.MethodsA line of ArExpand
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Detection of Chromosomal Aneuploidy in Human Preimplantation Embryos by Next-Generation Sequencing1
ABSTRACT Embryos produced by assisted reproductive technologies are commonly associated with a high level of aneuploidy. Currently, 24-chromosome profiling of embryo biopsy samples by array-basedExpand
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Endogenous EGF maintains Sertoli germ cell anchoring junction integrity and is required for early recovery from acute testicular ischemia/reperfusion injury.
Administration of exogenous epidermal growth factor (EGF) improves testicular injury after acute ischemia-reperfusion (IR) stress, but the molecular basis is poorly understood. The role of endogenousExpand
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Effects of electromagnetic radiation on morphology and TGF-β3 expression in mouse testicular tissue.
Exposure to electromagnetic pulses in certain doses may lead to increase in the permeability of the blood testes barrier (BTB) in mice, which in turn affects spermatogenesis, penetration andExpand
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Partial least squares-based gene expression analysis in preeclampsia.
  • F. Jiang, Y. Yang, +7 authors G. Wu
  • Medicine, Biology
  • Genetics and molecular research : GMR
  • 18 June 2015
Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression betweenExpand
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[Effects of electromagnetic pulses on apoptosis and TGF-β3 expression of mouse testis tissue].
OBJECTIVE To investigate the effects of electromagnetic pulses (EMP) on the apoptosis and transforming growth factor beta 3 (TGF-β3) expression of mouse testis tissue. METHODS Thirty-two maleExpand