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BACKGROUND   To assess the indications for and graft outcomes of penetrating keratoplasty (PK) in a tertiary hospital in China. DESIGN   A retrospective analysis of hospital records of patients, who had undergone PK at the First Affiliated Hospital of Zhejiang University in China over a 10-year period, was performed. PARTICIPANTS   A total of 203 eyes(More)
Posterior polymorphous corneal dystrophy (PPCD) is an extremely rare, bilateral, and inherited disorder, which affects the corneal endothelium and Descemet's membrane. Few PPCD cases in Chinese patients have been published so far. As far as we know, there are few studies which focused on the associations between PPCD and high myopia either. Here we report a(More)
A systematic search of the China National Knowledge Infrastructure database for articles on endophthalmitis after cataract surgery between 1995 and 2009 identified 57 articles that included 403 eyes. The incidence of endophthalmitis after cataract surgery was 0.06% (140/233,115). Treatments included intraocular antibiotic injection in 54.1% of eyes and(More)
OBJECTIVE To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. METHODS Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the patients before and after pterygium(More)
OBJECTIVE To evaluate the efficacy, safety and stability of posterior chamber phakic intraocular lens (PIOLs) implantation for the correction of high myopia. METHODS Thirty-nine eyes of twenty patients with high myopia (between -11.75 and -25.75 diopters) had a posterior chamber PIOL (Staar ICL) implanted. During 6 - 48 months' follow-up, visual acuity,(More)
BACKGROUND Seasonal allergic conjunctivitis (SAC) is caused by seasonal allergens and usually manifests as ocular itching and bulbar conjunctival injection (redness). Treatment options for SAC include corticosteroids and dual-acting antihistamine and mast-cell stabilizers. OBJECTIVE Our objective was to compare the efficacy and tolerability of loteprednol(More)
Lattice corneal dystrophy (LCD), characterized by the accumulation of amyloid within the cornea, is one of the most common inherited corneal diseases. Mutations in the human transforming growth factor beta-induced gene (TGFBI), formerly designated BIGH3, have been shown to be associated with different forms of LCD, including LCD type I (LCDI) and type IIIA(More)
AIMS To compare the efficacy and safety of 3% diquafosol ophthalmic solution with those of 0.1% sodium hyaluronate ophthalmic solution in patients with dry eye in China and Singapore. METHODS A total of 497 patients with dry eye (Schirmer's test, 5 mm; fluorescein and RB score, 3 points) from China and Singapore were randomised to receive either(More)
OBJECTIVE To compare the efficacy and safety of loteprednol etabonate 0.5%/tobramycin 0.3% (LE/T) and dexamethasone 0.1%/tobramycin 0.3% (DM/T) ophthalmic suspensions in a Chinese population with ocular inflammation associated with blepharokeratoconjunctivitis (BKC). RESEARCH DESIGN AND METHODS This study was a multicenter, randomized,(More)
PURPOSE To gain insight into the mechanisms underlying the transforming growth factor-beta induced (TGFBI)-related corneal dystrophies and the influence of the Arg555Trp and Thr538Pro, TGFBI mutations on C-terminal cleavage and cell endoplasmic reticulum (ER) stress were investigated. METHODS The Arg555Trp and Thr538Pro mutations known to be associated(More)