Horseradish peroxidase biosensor based on layer-by-layer technique for the determination of phenolic compounds
Modeling of peptides containing D-amino acids: implications on cyclization
- A. Yongye, Yangmei Li, M. Giulianotti, Yongping Yu, R. Houghten, K. Martínez-Mayorga
- Chemistry, BiologyJ. Comput. Aided Mol. Des.
- 11 July 2009
Refinement of the force field is expected to provide far-reaching conformational sampling of peptides containing D-residues to further develop force field-based conformational-searching methods.
A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
The structural and biochemical insights reported here provide the basis for developing new ERK inhibitors that are not ATP-competitive but instead function by disrupting critical protein-protein interactions.
Enhanced degradation of ofloxacin by persulfate activation with Mn doped CuO: Synergetic effect between adsorption and non-radical activation
Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?
High Throughput Synthesis of 2,3,6-Trisubstituted-5,6-Dihydroimidazo[2,1-b]thiazole Derivatives.
Insight into the mechanism of CuO activated persulfate with the assistance of bicarbonate for removing organic pollutants
The role of imidazole in peptide cyclization by transesterification: parallels to the catalytic triads of serine proteases.
- K. Byler, Yangmei Li, R. Houghten, K. Martínez-Mayorga
- Chemistry, BiologyOrganic and biomolecular chemistry
- 17 April 2013
This work used transition state analysis to explore the mechanism of the imidazole-catalyzed esterification of one such peptide, Ac-SAFYG-SCH2φ, and determined the acyl substitution product to be an intermediate in a competing reaction pathway involving acyl substituted of the thioester by imidrazole.
Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions.
- Yangmei Li, A. Yongye, M. Giulianotti, K. Martínez-Mayorga, Yongping Yu, R. Houghten
- ChemistryJournal of combinatorial chemistry
- 6 October 2009
A promising method for the synthesis of cyclic peptides through the direct aminolysis of peptide thioesters is presented and studies on the N- and C-terminal residues show that the choice of C-Terminal residue has a more significant effect on the success rate of cyclization.
Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.
Two cyclic peptides exhibited high binding affinities to opioid receptor and were selective for the mu-opioid receptor in a binding assay for mu opioid receptor.