Yang-xi Chen

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Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised. Despite the promise of embryonic(More)
Severe toothache can be caused by dental pulp inflammation. The ionotropic purinergic receptor family (P2X) is reported to mediate nociception in primary afferent neurons. This study aims to investigate the involvement of P2X receptors in the sensitization of the trigeminal ganglion (TG) caused by dental pulp inflammation. Lipopolysaccharides were(More)
OBJECTIVE To investigate the regulation of P2X3 protein expression in the trigeminal ganglion sensory neurons after the nociceptive stimulation by orthodontic tooth movement force. METHODS Male Sprague-Dawley rats weighing 200-250 g were used. The mimic tooth movement appliance was used in experimental group rats. The animals were sacrificed after 4 h, 1(More)
Odontogenesis consists of a series of consecutive tooth morphogenesis stages, in which apoptosis is involved to eliminate the unnecessary cells. Autophagy, a lysosome or endosome-mediated self-degradation process, is indicated to participate in embryogenesis and tissue morphogenesis associated with apoptosis. This study hypothesized that autophagy may be(More)
INTRODUCTION Aging people's bone regeneration potential is always impaired. Bone marrow stromal cells (MSCs) contain progenitors of osteoblasts. Donor age may affect MSCs' proliferation and differentiation potential, but the genomic base is still unknown. Due to recent research's indication that a core circadian component, brain and muscle ARNT-like 1(More)
AIM The aim of this survey was to compare Chinese natives and foreign inhabitants in Chengdu, China, with respect to: (1) attitudes towards dental appearance, (2) subjective orthodontic treatment need, and (3) the main factors influencing orthodontic treatment need. METHODOLOGY A total of 522 subjects, including 227 foreign inhabitants and 295 Chinese(More)
INTRODUCTION To understand the effects of low-magnitude, high-frequency (LMHF) mechanical vibration at different intensities on human periodontal ligament stem cell (hPDLSC) proliferation and osteogenic differentiation. MATERIAL AND METHODS The effect of vibration on hPDLSC proliferation, osteogenic differentiation, tenogenic differentiation and(More)
To observe the periodontal healing of autogenously transplanted teeth loaded orthodontically after autotransplantation in Beagle dogs. Forty-eight teeth were autogenously transplanted, 24 of which were loaded postoperatively with orthodontic force at different time points and for different durations. Periodontal healing was evaluated by probing pocket depth(More)
OBJECTIVE To investigate the regulation of P2X3 mRNA expression in the trigeminal ganglion sensory neurons after the nociceptive stimulation by orthodontic tooth movement force. METHODS Male Sprague-Dawley rats weighing 200-250 g were used. The mimic tooth movement appliance was used in the rats of the experiment group. The rats were sacrificed after 4 h,(More)
OBJECTIVE To explore the effects of applying force during the different stages of estrous cycle on orthodontic tooth movement of rats, so as to offer an experimental princinple for women's orthodontic treatment. METHODS 80 female 3-month-old Wistar rats, which had a stable and five-day estrous cycle, were used. They were randomly divided into control(More)