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Journals and Conferences
Abstract A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those… (More)
The preparation of 4- and 5-acyl- and aroyl-2-substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4,5-disubstituted-2-aminothiazoles and… (More)
Abstract Peptidic prodrugs of the five most active aminomethyl-THF 1β-methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from 1a demonstrated an improved oral activity. These… (More)
Abstract A more extensive investigation of the solvolysis of the 3-bicyclo-[3.1.0]hexyl tosylates has been carried out using kinetic, NMR and VPC techniques not employed previously. For labeled… (More)
A series of new 2,3-diamino-4-pyrimidinones and 3-amino-2-hydrazino-4-pyrimidinones were synthesized by the reactions of β-ketoesters with amino or diaminoguanidines.
[(1-Amino-6-hydroxy-2(1H)-pyrimidinylidene)hydrazone]butanedioic acid dimethyl esters 3, formed from 3-amino-2-hydrazino-4(3H)-pyrimidinones and dimethyl acetylenedicarboxylate in acetic acid at room… (More)
This specification describes platinum complexes of 3beta, 4alpha-diamino-1alpha, 2alfa-cyclohexanediol, which have the property of inhibiting tumor growth in mammals.
A one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate 11 has been developed. The condensation of ethyl 2-pyridylacetate and 2,4,5-trifluorobenzoyl chloride followed by… (More)