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The goal of graph clustering is to partition vertices in a large graph into different clusters based on various criteria such as vertex con-nectivity or neighborhood similarity. Graph clustering techniques are very useful for detecting densely connected groups in a large graph. Many existing graph clustering methods mainly focus on the topological structure(More)
Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas sp. The DNA-binding domain of each TALE consists of tandem 34-amino acid repeat modules that can be rearranged according to a simple cipher to target new DNA sequences. Customized TALEs can be used for a wide variety(More)
The corpus callosum is the largest commissural system in the mammalian brain, but the mechanisms underlying its development are not well understood. Here we report that neuronal activity is necessary for the normal development and maintenance of callosal projections in the mouse somatosensory cortex. We labeled a subpopulation of layer II/III callosal(More)
Late-phase long-term potentiation (L-LTP) and long-term memory depend on the transcription of mRNA of CRE-driven genes and synthesis of proteins. However, how synaptic signals propagate to the nucleus is unclear. Here we report that the CREB coactivator TORC1 (transducer of regulated CREB activity 1) undergoes neuronal activity-induced translocation from(More)
Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing "glial transmitters," such as glutamate, ATP, and D-serine. Unlike the case for neurons, the mechanisms by which glia release transmitters are essentially unknown. Here, by using electrochemical(More)
Bug localization has attracted a lot of attention recently. Most existing methods focus on pinpointing a single statement or function call which is very likely to contain bugs. Although such methods could be very accurate, it is usually very hard for developers to understand the context of the bug, given each bug location in isolation. In this study, we(More)
In this letter, we propose a novel scheme to reduce the PAPR of OFDM signals, and its key idea is that the side information of partial transmit sequence is considered as a part of channel frequency response. Therefore, the proposed scheme does not need to reserve bits for submitting side information, resulting in an increase in the data rate. Furthermore,(More)
CREB-target gene transcription during neuronal excitation is important for many aspects of neuronal development and function, including dendrite morphogenesis. However, the signaling events that regulate cAMP response element-binding protein (CREB)-mediated gene transcription during dendritic development are not well understood. Herein we report that the(More)