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Many scientific disciplines are now data and information driven, and new scientific knowledge is often gained by scientists putting together data analysis and knowledge discovery " pipelines ". A related trend is that more and more scientific communities realize the benefits of sharing their data and computational services, and are thus contributing to a(More)
Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin(More)
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. Here, we show that pluripotent stem cells(More)
In this brief, a novel local descriptor, named local binary count (LBC), is proposed for rotation invariant texture classification. The proposed LBC can extract the local binary grayscale difference information, and totally abandon the local binary structural information. Although the LBC codes do not represent visual microstructure, the statistics of LBC(More)
The transition from dormancy to germination in seeds is a key physiological process during the lifecycle of plants. Abscisic acid (ABA) is the sole plant hormone known to maintain seed dormancy; it acts through a gene expression network involving the transcription factor ABSCISIC ACID INSENSITIVE 3 (ABI3). However, whether other phytohormone pathways(More)
UNLABELLED The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for therapeutic applications. We report a novel three-stage method to efficiently direct the differentiation of human embryonic stem cells into hepatic cells in serum-free medium. Human ESCs were first differentiated into definitive endoderm cells by 3 days of(More)
Recently, direct reprogramming between divergent lineages has been achieved by the introduction of regulatory transcription factors. This approach may provide alternative cell resources for drug discovery and regenerative medicine, but applications could be limited by the genetic manipulation involved. Here, we show that mouse fibroblasts can be directly(More)
Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from primates resemble mouse epiblast stem cells, raising an intriguing question regarding whether the naive pluripotent state resembling mouse embryonic stem cells (mESCs) exists in primates and how to capture it in vitro. Here we identified several specific(More)
MEK/ERK signaling plays a crucial role in a diverse set of cellular functions including cell proliferation, differentiation and survival, and recently has been reported to negatively regulate mouse embryonic stem cell (mESC) self-renewal by antagonizing STAT3 activity. However, its role in human ESCs (hESCs) remains unclear. Here we investigated the(More)
Yang Zhao,1,4 Xiaolei Yin,1,2,4 Han Qin,1,2,4 Fangfang Zhu,1,2,5 Haisong Liu,1,2,5 Weifeng Yang,1,5 Qiang Zhang,1,2,5 Chengang Xiang,1,2,5 Pingping Hou,1,5 Zhihua Song,1,2 Yanxia Liu,1,2 Jun Yong,1 Pengbo Zhang,1 Jun Cai,1 Meng Liu,1,2 Honggang Li,1 Yanqin Li,1 Xiuxia Qu,1 Kai Cui,1 Weiqi Zhang,1 Tingting Xiang,1 Yetao Wu,1,2 Yiding Zhao,1 Chun Liu,1,2 Chen(More)