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Microglia are phagocytic cells that infiltrate the brain during development and have a role in the elimination of synapses during brain maturation. Changes in microglial morphology and gene expression have been associated with neurodevelopmental disorders. However, it remains unknown whether these changes are a primary cause or a secondary consequence of(More)
BACKGROUND How oscillatory brain rhythms alone, or in combination, influence cortical information processing to support learning has yet to be fully established. Local field potential and multi-unit neuronal activity recordings were made from 64-electrode arrays in the inferotemporal cortex of conscious sheep during and after visual discrimination learning(More)
  • Duo Xu, Yang Zhan, +10 authors Yan Dong
  • 2015
Constitutively active androgen receptor splice variants (AR-V) lacking the ligand-binding domain have been implicated in the pathogenesis of castration-resistant prostate cancer and in mediating resistance to newer drugs that target the androgen axis. AR-V regulates expression of both canonical AR targets and a unique set of cancer-specific targets that are(More)
STUDY OBJECTIVES To explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences. METHODS Forty-two PCPIs (27 females, 15 males) and 42 good sleepers (GSs; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. Amplitude of(More)
Applications frequently request file system operations that traverse the file system directory tree, such as opening a file or reading a file's metadata. As a result, caching file system directory structure and metadata in memory is an important performance optimization for an OS kernel. This paper identifies several design principles that can(More)
Various time-frequency methods have been used to study time-varying properties of non-stationary neurophysiological signals. In the present study, a time-frequency coherence estimate using continuous wavelet transform (CWT) together with its confidence intervals are proposed to evaluate the correlation between two non-stationary processes. The approach is(More)
Upregulation of constitutively-active androgen receptor splice variants (AR-Vs) has been implicated in AR-driven tumor progression in castration-resistant prostate cancer. To date, functional studies of AR-Vs have been focused mainly on their ability to regulate gene expression independent of the full-length AR (AR-FL). Here, we showed that AR-V7 and(More)
Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. Behavioral analysis of constitutive Cdkl5 knockout mice(More)
The B ε-tree File System, or BetrFS, (pronounced " better eff ess ") is the first in-kernel file system to use a write-optimized index. Write optimized indexes (WOIs) are promising building blocks for storage systems because of their potential to implement both microwrites and large scans efficiently. Previous work on WOI-based file systems has shown(More)