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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested for induction of the IL-8Expand
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The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Numerous bacteria cope with the scarcity of iron in their microenvironment by synthesizing small iron-scavenging molecules known as siderophores. Mammals have evolved countermeasures to blockExpand
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Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzymeExpand
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Mus81 and converging forks limit the mutagenicity of replication fork breakage
How to repair broken replication forks Double-strand breaks in DNA are extremely dangerous to the integrity of our genomes. Most arise from problems encountered by replication forks duringExpand
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MiR397b regulates both lignin content and seed number in Arabidopsis via modulating a laccase involved in lignin biosynthesis.
Plant laccase (LAC) enzymes belong to the blue copper oxidase family and polymerize monolignols into lignin. Recent studies have established the involvement of microRNAs in this process; however,Expand
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Panoramix enforces piRNA-dependent cotranscriptional silencing
A Gaulish partner in silencing transposons Small noncoding piRNAs protect animal germline genomes from devastating mutation and rearrangement caused by transposons. In fruit fly ovaries, piRNAs bindExpand
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Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition
Alternative splicing makes a major contribution to proteomic diversity in higher eukaryotes with approximately 70% of genes encoding two or more isoforms. In most cases, the molecular mechanismsExpand
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Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor‐dependent inhibition of glycogen synthase kinase‐3β and a receptor‐independent anti‐oxidative action
3‐methyl‐6‐chloro‐7,8‐hydroxy‐1‐(3‐methylphenyl)‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepine (SKF83959), a selective agonist for the putative phosphatidylinositol (PI)‐linked dopamine receptor (DAR), hasExpand
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A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.
DNA double-strand breaks (DSBs) are a major threat to genome integrity. Proteins involved in DNA damage checkpoint signaling and DSB repair often relocalize and concentrate at DSBs. Here, we used anExpand
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Generation and characterization of transgenic poplar plants overexpressing a cotton laccase gene
Laccases are copper-containing glycoproteins, which are widespread in higher plants as multigene families. To gain more insight in the function of laccases in plants, especially potential role inExpand
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