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Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling
It is demonstrated that melatonin attenuates sepsis‐induced brain injury via SIRT1 signaling activation, and improves survival rate, attenuated brain edema and neuronal apoptosis, and preserved BBB integrity.
Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling
Melatonin treatment attenuates the EBI following SAH by inhibiting NLRP3 inflammasome‐associated apoptosis, which is reported to possess substantial anti‐inflammatory properties.
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1‐dependent mechanism during ischemic‐stroke in mice
Melatonin treatment attenuates cerebral IRI by reducing IR‐induced mitochondrial dysfunction through the activation of SIRT1 signaling, and is demonstrated to result in a well‐preserved mitochondrial membrane potential, mitochondrial Complex I activity, and mitochondrial cytochrome c level.
An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders.
LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging
Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling
ERS activation may represent a mechanism of action for the anticancer activity of ICA in ESCCs, and the activation of ERS signaling may represents a novel therapeutic intervention for human esophageal cancer.
PGC-1: The Energetic Regulator in Cardiac Metabolism.
The significant roles of P GC-1s in cardiac metabolism are presented and may contribute to the promotion of PGC-1 signaling pathway as a novel therapeutic target.
HO-1 Signaling Activation by Pterostilbene Treatment Attenuates Mitochondrial Oxidative Damage Induced by Cerebral Ischemia Reperfusion Injury
It is demonstrated that PTE treatment attenuates cerebral IRI by reducing IR-induced mitochondrial oxidative damage through the activation of HO-1 signaling.
Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis
The crucial roles of STAT3 in endothelial cell dysfunction, macrophage polarization, inflammation, and immunity during atherosclerosis, and some of the problems that have interfered with the development of mature therapies utilizing STAT3 inhibitors to treat Atherosclerosis are described.