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Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.
TLDR
Tregs are associated with HCC invasiveness, and intratumoral balance of regulatory and cytotoxic T cells is a promising independent predictor for recurrence and survival in HCC. Expand
Systemic Immune-Inflammation Index Predicts Prognosis of Patients after Curative Resection for Hepatocellular Carcinoma
TLDR
The novel systemic immune-inflammation index (SII) based on lymphocyte, neutrophil, and platelet counts was a powerful prognostic indicator of poor outcome in patients with HCC and is a promising tool for HCC treatment strategy decisions. Expand
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
TLDR
DKK1 could complement measurement of AFP in the diagnosis of HCC and improve identification of patients with AFP-negative H CC and distinguish HCC from non-malignant chronic liver diseases. Expand
Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma
TLDR
The data suggest for the first time that PD-L1 status may be a new predictor of recurrence for HCC patients and provide the rationale for developing a novel therapy of targeting the PD- L1/PD-1 pathway against this fatal malignancy. Expand
Circulating stem cell–like epithelial cell adhesion molecule–positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
TLDR
Stem cell–like phenotypes are observed in EpCAM+ CTCs, and a preoperative CTC7.5 of ≥2 is a novel predictor for tumor recurrence in HCC patients after surgery, especially in patient subgroups with AFP levels of ≤400 ng/mL or low tumor recurrent risk. Expand
Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas.
TLDR
Elevated expression of DKK1, alone or combined with beta-catenin, is a novel prognostic predictor for HCC patients and is a critical event in patients with HCC that indicates poor clinical outcome. Expand
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma.
TLDR
Exposure of autophagic genes and their corresponding autophile activities were suppressed in HCC, suggesting that the autophagy defects synergized with altered apoptotic activity might facilitate tumor malignant differentiation, which results in a more aggressive cancer cell phenotype and poor prognosis of HCC. Expand
Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance
TLDR
The efficacy of circulating tumor cell (CTC) detection among patients with solid malignancy has been investigated, which shows great potential to become a tool for real-time parameter of prognosis and serve as an early marker to assess the therapeutic response in overt cancers. Expand
Role of overexpression of CD151 and/or c‐Met in predicting prognosis of hepatocellular carcinoma
TLDR
CD151 is positively associated with invasiveness of HCC, and CD151 or combination of CD151/c‐Met is a novel marker in predicting the prognosis of H CC and a potential therapeutic target. Expand
High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma
TLDR
The simplified model based on the HSC/HPC and tumour angiogenesis profile can be used to classify patients with HCC with a high risk of tumour recurrence after surgery. Expand
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