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Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
Evidence is provided that LSD1 (KIAA0601), a nuclear homolog of amine oxidases, functions as a histone demethylase and transcriptional corepressor and RNAi inhibition of LSD1 causes an increase in H3 lysine 4 methylation and concomitant derepression of target genes, suggesting that LSD 1 represses transcription via histonedemethylation. Expand
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes. Expand
Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein
A sequence within the transcription control region of the adeno-associated virus P5 promoter has been shown to mediate transcriptional activation by the adenovirus E1A protein. We report here thatExpand
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
The finding that this family of demethylases generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation. Expand
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
A novel class of methylated H3K4 effector domains—the PHD domains of the ING (for inhibitor of growth) family of tumour suppressor proteins—are identified and established a pivotal role for trimethylation of H 3K4 in gene repression and, potentially, tumour suppressing mechanisms. Expand
Coordinated histone modifications mediated by a CtBP co-repressor complex
The identification of a CtBP complex that contains the essential components for both gene targeting and coordinated histone modifications, allowing for the effective repression of genes targeted by CtBP is reported. Expand
Histone methylation: a dynamic mark in health, disease and inheritance
This work provides a broad overview of how histone methylation is regulated and leads to biological outcomes and suggests its links to disease and ageing and possibly to transmission of traits across generations are illustrated. Expand
New Nomenclature for Chromatin-Modifying Enzymes
The aim of this exhibition was to celebrate the 50th anniversary of the United States Declaration of Independence with a celebration of those who served in the armed forces and those who sacrificed in the conflicts of World War II. Expand
Regulation of LSD1 histone demethylase activity by its associated factors.
It is shown that CoREST endows LSD1 with the ability to demethylate nucleosomal substrates and that it protects LSD1 from proteasomal degradation in vivo, suggesting that hypoacetylated nucleosomes may be the preferred physiological substrate. Expand
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.
The data suggest that Tet1 controls DNA methylation both by binding to CpG-rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5mC to 5hmC through hydroxylase activity. Expand