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In this paper we show that Wenckebach-like patterns of intracellular calcium concentration, [Ca2+]i, arise in non-excitable cell models when driven repetitively by the application of agonists that activate the phospholinositide-signalling pathway. These patterns are similar to action potential responses observed in excitable cells when driven periodically(More)
We examined the effects of brief current pulses on the pacemaker oscillations of the Purkinje fiber using the model of McAllister , Noble, and Tsien (1975. J. Physiol. [Lond.]. 251:1-57). This model was used to construct phase-response curves for brief electric stimuli to find "black holes," where rhythmic activity of the Purkinje fiber ceases. In our(More)
With the dynamic differential equations of Beeler, G. W., and H. Reuter (1977, J. Physiol. [Lond.]. 268:177-210), we have studied the oscillatory behavior of the ventricular muscle fiber stimulated by a depolarizing applied current I app. The dynamic solutions of BR equations revealed that as I app increases, a periodic repetitive spiking mode appears above(More)
A mathematical model previously developed to explain beta-cell membrane potential oscillations has been modified to accommodate the external variation of K+, Na+ and Ca2+ concentrations. Our model, which is applicable to excitable cells, incorporates the barrier kinetics. Hodgkin-Huxley-type gating mechanism, and an electrogenic Na+-K+ pump. Numerical(More)
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