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An emerging concept is that cancers strongly depend on both internal and external signals for growth and invasion. In this review, we will discuss pathological and physical changes in the tumor microenvironment and how these changes can be exploited to design gold nanoparticles for cancer diagnosis and therapy. These intrinsic changes include extracellular(More)
Parkinson's disease (PD) is a progressive neurological disorder of CNS and one of the most common neurodegenerative diseases. The exact mechanisms underlying PD has been unclear but it is believed that multiple factors are involved. Excessive exposure to manganese (Mn) can causes its accumulation in the human brain and subsequent neural damage and even(More)
High efficiency dry face milling experiments on powder metallurgy superalloy, were conducted using coated carbide tools. The approach to prolong the service life of the TiAlN-TiN coated carbide tool in milling powder metallurgy superalloy is presented. By the use of SEM and energy spectrometer, the wear morphology and mechanisms of rake face and flank wear(More)
Sialic acid (SA) is an important nutrient but few studies have examined the link between dietary intake and breast milk sialic acid. The purpose of this observational study was to assess the potential relationship between human breast milk sialic acid levels and dietary nutrition intake 40 d postpartum. The study population included 90 healthy women who(More)
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