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- Zhihua Chen, Hilaire C. Lam, +7 authors Augustine M. K. Choi
- Proceedings of the National Academy of Sciences…
- 2010
Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (i.e., emphysema). The… (More)
- Shu-bai Liu, Ying-ying He, +4 authors Yang Jin
- PloS one
- 2008
BACKGROUND
In vertebrates, non-lens betagamma-crystallins are widely expressed in various tissues, but their functions are unknown. The molecular mechanisms of trefoil factors, initiators of mucosal… (More)
- Seon-Jin Lee, Akaya Smith, +12 authors Augustine M. K. Choi
- American journal of respiratory and critical care…
- 2011
RATIONALE
Pulmonary hypertension (PH) is a progressive disease with unclear etiology. The significance of autophagy in PH remains unknown.
OBJECTIVES
To determine the mechanisms by which autophagic… (More)
- Gee Young Suh, Yang Jin, A E Yi, Xiao Mei Wang, Augustine M. K. Choi
- American journal of respiratory cell and…
- 2006
Cyclooxygenase-2 (COX-2) is a key enzyme involved in the inflammatory process that is rapidly induced in macrophages in response to LPS. Carbon monoxide (CO), a byproduct of heme oxygnease-1, can… (More)
- Akihiko Tanaka, Yang Jin, +5 authors Augustine M. K. Choi
- American journal of respiratory cell and…
- 2012
Epithelial cell death plays a critical role in hyperoxia-induced lung injury. We investigated the involvement of the autophagic marker microtubule-associated protein-1 light chain-3B (LC3B) in… (More)
- Yang Jin, Wen-Hui Lee, Lin Zeng, Yun Zhi Zhang
- Toxicon : official journal of the International…
- 2007
An L-amino acid oxidase from Ophiophagus hannah snake venom (Oh-LAAO) was purified by successive gel filtration, ion-exchange and heparin chromatography. Oh-LAAO did not induce platelet aggregation;… (More)
- Ling Wang, Yang Jin, +8 authors Fahri Saatcioglu
- Cancer research
- 2010
STAMP1 is predicted to encode a six-transmembrane protein whose expression is highly prostate enriched and is deregulated in prostate cancer. However, the biological role of STAMP1 in prostate cancer… (More)
- Qi Huang, Limin Duan, +10 authors Yang Jin
- Scientific reports
- 2016
Inflammation and angiogenesis are two hallmarks of carcinoma. The proinflammatory cytokine interleukin-17 (IL-17) facilitates angiogenesis in lung cancer; however, the underlying mechanism is not… (More)
Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1.
- Yang Jin, Hong Pyo Kim, Minli Chi, Emeka Ifedigbo, Stefan W. Ryter, Augustine M. K. Choi
- American journal of respiratory cell and…
- 2008
Acute lung injury (ALI) is a major cause of morbidity and mortality in critically ill patients. Hyperoxia causes lung injury in animals and humans, and is an established model of ALI. Caveolin-1, a… (More)
- Ling Lin, Yang Jin, Wendy M. Mars, W. Brian Reeves, Kebin Hu
- The American journal of pathology
- 2014
Macrophage accumulation is one of the hallmarks of progressive kidney disease. Tissue-type plasminogen activator (tPA) is known to promote macrophage infiltration and renal inflammation during… (More)