Learn More
Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received gene therapy after nonmyeloablative bone marrow conditioning for the treatment of X-linked chronic granulomatous disease (X-CGD), a primary immunodeficiency caused by a defect in the(More)
We propose and solve the optimal-location query in spatial databases. Given a set S of sites, a set O of weighted objects, and a spatial region Q, the optimal-location query returns a location in Q with maximum influence. Here the influence of a location l is the total weight of its RNNs, i.e. the total weight of objects in O that are closer to l than to(More)
Given a set O of weighted objects, a set S of sites, and a query site s, the bichromatic RNN query computes the influence set of s, or the set of objects in O that consider s as the nearest site among all sites in S. The influence of a site s can be defined as the total weight of its RNNs. This paper addresses the new and interesting problem of finding the(More)
This paper proposes and solves the Time-Interval All Fastest Path (allFP) query. Given a user-defined leaving or arrival time interval I, a source node s and an end node e, allFP asks for a set of all fastest paths from s to e, one for each sub-interval of I. Note that the query algorithm should find a partitioning of I into sub-intervals. Existing methods(More)
This paper proposes and solves the min-dist optimal-location query in spatial databases. Given a set <i>S</i> of sites, a set <i>O</i> of weighted objects, and a spatial region <i>Q</i>, the min-dist optimal-location query returns a location in <i>Q</i> which, if a new site is built there, minimizes the average distance from each object to its closest site.(More)
Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated in the pathophysiology of neurodegenerative disorders. Although transcriptional regulation of the BDNF gene (Bdnf) has been extensively studied, much(More)
Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed(More)
This paper presents the first theoretical study, on using local-recoding generalization (LRG) to compute a k-anonymous table with quality guarantee. First, we prove that it is NP-hard both to find the table with the maximum quality, and to discover a solution with an approximation ratio at most 5/4. Then, we develop an algorithm with good balance between(More)
The compatible solute ABC (ATP-binding cassette) transporters are indispensable for acquiring a variety of compatible solutes under osmotic stress in Bacillus subtilis. The substrate-binding protein OpuCC (Opu is osmoprotectant uptake) of the ABC transporter OpuC can recognize a broad spectrum of compatible solutes, compared with its 70% sequence-identical(More)
Here we report whole-exome sequencing of individuals with various myeloid malignancies and identify recurrent somatic mutations in SETBP1, consistent with a recent report on atypical chronic myeloid leukemia (aCML). Closely positioned somatic SETBP1 mutations encoding changes in Asp868, Ser869, Gly870, Ile871 and Asp880, which match germline mutations in(More)