Learn More
Given a set O of weighted objects, a set S of sites, and a query site s, the bichromatic RNN query computes the influence set of s, or the set of objects in O that consider s as the nearest site among all sites in S. The influence of a site s can be defined as the total weight of its RNNs. This paper addresses the new and interesting problem of finding the(More)
We propose and solve the optimal-location query in spatial databases. Given a set S of sites, a set O of weighted objects, and a spatial region Q, the optimal-location query returns a location in Q with maximum influence. Here the influence of a location l is the total weight of its RNNs, i.e. the total weight of objects in O that are closer to l than to(More)
In a gate-level monolithic 3D IC (M3D), all the transistors in a single logic gate occupy the same tier, and gates in different tiers are connected using nano-scale monolithic inter-tier vias. This design style has the benefit of the superior power-performance quality offered by flat implementations (unlike block-level M3D), and zero total silicon area(More)
Although recent researches show that Heat Shock Protein 72 (HSP72) plays an important role in neuronal survival, little knowledge is known about the precise mechanisms during cerebral ischemia/reperfusion (I/R). Our present study investigated the neuroprotective mechanisms of HSP72 against ischemic brain injury induced by cerebral I/R. Mild heat shock(More)
Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated in the pathophysiology of neurodegenerative disorders. Although transcriptional regulation of the BDNF gene (Bdnf) has been extensively studied, much(More)
Monolithic 3D is an emerging technology that enables integration density which is orders of magnitude higher than that offered by through-silicon-vias (TSV). In this paper we demonstrate that a modified 2D placement technique, coupled with a post-placement partitioning step, is sufficient to produce high quality monolithic 3D placement solutions. We also(More)
G-protein-coupled receptors (GPCRs) remain the primary conduit by which cells detect environmental stimuli and communicate with each other. Upon activation by extracellular agonists, these seven-transmembrane-domain-containing receptors interact with heterotrimeric G proteins to regulate downstream second messenger and/or protein kinase cascades.(More)
OBJECTIVES To investigate clinical features and potential mechanisms involving α-synuclein oligomer and inflammation in patients with Parkinson disease (PD) and probable REM sleep behavior disorder (PRBD). METHODS We used the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate patients with PD and classified each as PRBD or not(More)